Lee A Y, Nakagawa H, Nogita T, Ishibashi Y
Department of Dermatology, Faculty of Medicine, University of Tokyo, Japan.
J Cutan Pathol. 1989 Aug;16(4):211-7. doi: 10.1111/j.1600-0560.1989.tb00043.x.
An electron microscopic study was made of a patient with erythema elevatum diutinum, a rare variant of cutaneous leukocytoclastic vasculitis. Biopsies were obtained from early evolving and late fibroproliferative lesions. Early lesions showed vasculitis and a massive dermal infiltrate composed mainly of neutrophils, histiocytes/macrophages and apparently increased Langerhans cells. Later lesions were characterized by a dense fibrosis with a proliferation of fibroblasts and myofibroblasts and a dermal infiltrate in which lymphocytes and histiocytes/macrophages predominated. Even in later lesions, dermal Langerhans cells were observed in great number. Langerhans cells may be involved in the evolution of this rare disease.
对一名持久性隆起性红斑患者进行了电子显微镜研究，持久性隆起性红斑是皮肤白细胞破碎性血管炎的一种罕见变体。从早期演变阶段和晚期纤维增生性病变处获取活检组织。早期病变显示血管炎以及主要由中性粒细胞、组织细胞/巨噬细胞和明显增多的朗格汉斯细胞组成的大量真皮浸润。后期病变的特征是致密纤维化，伴有成纤维细胞和肌成纤维细胞增生以及以淋巴细胞和组织细胞/巨噬细胞为主的真皮浸润。即使在后期病变中，也观察到大量真皮朗格汉斯细胞。朗格汉斯细胞可能参与了这种罕见疾病的演变过程。
