LeBoit P E, Yen T S, Wintroub B
Am J Dermatopathol. 1986 Oct;8(5):392-402. doi: 10.1097/00000372-198610000-00005.
We obtained biopsies from early, fully developed, and late lesions of erythema elevatum diutinum (EED) in a 49-year-old man. The histologic and electron-microscopic findings were compared with those reported in the literature and three other cases from our files. Early lesions show leukocytoclastic vasculitis with capillary proliferation. Later lesions show vasculitis, dermal aggregates of neutrophils, fibrosis, and areas of granulation tissue. Newly formed vessels in granulation tissue may be more susceptible to damage by immune complexes, and the early formation of granulation tissue in EED may prevent an early resolution of vasculitis. Damage to dermal connective tissue in EED incites either scarring or, rarely, a fibrohistiocytic proliferation. Ultrastructural examination of one case showed histiocytes with myelin figures and intracellular lipid and cholesterol.
我们从一名49岁男性的持久性隆起性红斑（EED）的早期、完全发展期和晚期病变处获取了活检组织。将组织学和电子显微镜检查结果与文献报道以及我们档案中的其他三例病例进行了比较。早期病变表现为白细胞破碎性血管炎伴毛细血管增生。后期病变表现为血管炎、真皮内中性粒细胞聚集、纤维化和肉芽组织区域。肉芽组织中新生血管可能更易受到免疫复合物的损伤，EED中肉芽组织的早期形成可能会阻碍血管炎的早期消退。EED中真皮结缔组织的损伤会引发瘢痕形成，或很少见的纤维组织细胞增生。对一例病例的超微结构检查显示组织细胞含有髓鞘样结构以及细胞内脂质和胆固醇。
