Atiba Ayman, Ghazy Alaa, Gomaa Naglaa, Kamal Tarek, Shukry Mustafa
Department of Surgery, Anesthesiology and Radiology, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafrelsheikh 33516, Egypt.
Department of Animal Medicine, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafrelsheikh 33516, Egypt.
Vet Med Int. 2015;2015:575101. doi: 10.1155/2015/575101. Epub 2015 Dec 3.
Aim of this study was to compare the analgesic effect of tramadol and a combination of tramadol-lidocaine with that produced by lidocaine administration in the epidural space in buffalo calves. In a prospective randomized crossover study, ten male buffalo calves were used to compare the epidural analgesic effect of tramadol (1 mg/kg) and tramadol-lidocaine combination (0.5 mg/kg and 0.11 mg/kg, resp.) with that produced by 2% lidocaine (0.22 mg/kg). Loss of sensation was examined by pin-prick test. Onset time, duration, and degree of analgesia and ataxia were recorded after each treatment. Heart rate (HR), respiratory rate (RR), rectal temperature, and haematobiochemical parameters were recorded after all treatments. Time to onset and duration of analgesia, respectively, were as follows: tramadol 11 ± 2 min and 208 ± 15 min; tramadol-lidocaine 6 ± 2 min and 168 ± 9 min; lidocaine 4 ± 1 min and 67 ± 13 min. Onset time and duration were significantly longer with tramadol than the other treatments. Duration was significantly longer with tramadol-lidocaine than lidocaine. Ataxia was mildly observed in tramadol-lidocaine and was moderate in lidocaine. HR, RR, and rectal temperature did not differ significantly from baseline after any treatment. Haematobiochemical parameters returned to basal levels by 24 h after all treatments. This combination might be clinically useful to provide analgesia in buffalo for long-duration surgical procedures.
本研究的目的是比较曲马多以及曲马多与利多卡因联合用药，和在水牛犊硬膜外腔注射利多卡因所产生的镇痛效果。在一项前瞻性随机交叉研究中，选用10头雄性水牛犊，比较曲马多（1毫克/千克）、曲马多 - 利多卡因联合用药（分别为0.5毫克/千克和0.11毫克/千克）与2%利多卡因（0.22毫克/千克）的硬膜外镇痛效果。通过针刺试验检查感觉丧失情况。每次治疗后记录镇痛的起效时间、持续时间、程度以及共济失调情况。所有治疗后记录心率（HR）、呼吸频率（RR）、直肠温度和血液生化参数。镇痛的起效时间和持续时间分别如下：曲马多为11±2分钟和208±15分钟；曲马多 - 利多卡因联合用药为6±2分钟和168±9分钟；利多卡因为4±1分钟和67±13分钟。曲马多的起效时间和持续时间显著长于其他治疗方法。曲马多 - 利多卡因联合用药的持续时间显著长于利多卡因。在曲马多 - 利多卡因联合用药组轻度观察到共济失调，在利多卡因组为中度。任何治疗后HR、RR和直肠温度与基线相比均无显著差异。所有治疗后24小时血液生化参数恢复到基础水平。这种联合用药在水牛长时间外科手术中提供镇痛方面可能具有临床实用性。
