Ongstad Emily, Kohl Peter
Clemson University, Department of Bioengineering, Clemson, SC, USA; Virginia Tech Carilion Research Institute, Roanoke, VA, USA.
Institute for Experimental Cardiovascular Medicine, University Heart Centre Freiburg - Bad Krozingen, Faculty of Medicine, University Freiburg, Germany; Cardiac Biophysics and Systems Biology, National Heart and Lung Institute, Imperial College London, UK.
J Mol Cell Cardiol. 2016 Feb;91:238-46. doi: 10.1016/j.yjmcc.2016.01.010. Epub 2016 Jan 14.
Cardiac myocyte-fibroblast electrotonic coupling is a well-established fact in vitro. Indirect evidence of its presence in vivo exists, but few functional studies have been published. This review describes the current knowledge of fibroblast-myocyte electrical signaling in the heart. Further research is needed to understand the frequency and extent of heterocellular interactions in vivo in order to gain a better understanding of their relevance in healthy and diseased myocardium. It is hoped that associated insight into myocyte-fibroblast coupling in the heart may lead to the discovery of novel therapeutic targets and the development of agents for improving outcomes of myocardial scarring and fibrosis.
心肌细胞与成纤维细胞之间的电紧张偶联在体外已是公认的事实。体内存在其存在的间接证据,但发表的功能研究较少。这篇综述描述了目前关于心脏中成纤维细胞与心肌细胞电信号传导的知识。需要进一步研究以了解体内异细胞相互作用的频率和程度,以便更好地理解它们在健康和患病心肌中的相关性。希望对心脏中心肌细胞与成纤维细胞偶联的相关见解可能会导致发现新的治疗靶点,并开发出改善心肌瘢痕形成和纤维化结果的药物。