Neuroscience and Aphasia Research Unit, School of Biological Sciences, University of Manchester, UK;; Department of Psychology, University of Cambridge, UK.
Neuroscience and Aphasia Research Unit, School of Biological Sciences, University of Manchester, UK;; MRC Cognition and Brain Sciences Unit, University of Cambridge, UK.
Neuroimage Clin. 2018 Aug 21;20:611-619. doi: 10.1016/j.nicl.2018.08.022. eCollection 2018.
Linking both structural lesions and the functional integrity of remaining brain tissue to patients' behavioural profile may be critical in discovering the limits of behavioural recovery post stroke. In the present study, we explored the relationship between temporal hemodynamic changes and language performance in chronic post-stroke aphasia. We collected detailed language and neuropsychological data for 66 patients with chronic (>1 year) post-stroke aphasia. We used principal component analysis to extract their core language-neuropsychological features. From resting-state fMRI scans in 35 patients, we calculated the lag in the time-course of the intact brain voxels in each patient. Finally, variation across the language-cognitive factors was related to both the patients' structural damage and the time-course changes in each patient's intact tissue. Phonological abilities were correlated with the structural integrity of the left superior temporal, angular gyrus, supramarginal gyrus and arcuate fasciculus regions and hemodynamic advance in the left intra-parietal sulcus. Speech fluency related to integrity of premotor regions, plus hemodynamic advance in the left middle/superior temporal gyrus, left middle occipital gyrus, and right angular gyrus. Semantic performance reflected a combination of medial ventral temporal lobe status and hemodynamic delay in the left posterior middle temporal gyrus. Finally, executive abilities correlated with hemodynamic delay in the left middle/inferior frontal gyrus, right rolandic operculum, bilateral supplementary motor areas/middle cingulum areas, and bilateral thalamus/caudate. Following stroke, patients' patterns of chronic language abilities reflects a combination of structural and functional integrity across a distributed network of brain regions. The correlation between hemodynamic changes and behaviours may have clinical importance.
将结构损伤与剩余脑组织的功能完整性与患者的行为特征联系起来，对于发现中风后行为恢复的极限可能至关重要。在本研究中，我们探讨了慢性中风后失语症患者的时间性血液动力学变化与语言表现之间的关系。我们收集了 66 例慢性（>1 年）中风后失语症患者的详细语言和神经心理学数据。我们使用主成分分析提取了他们的核心语言-神经心理学特征。在 35 例患者的静息状态 fMRI 扫描中，我们计算了每个患者完整脑体素时程的滞后。最后，语言认知因素的变化与患者的结构损伤以及每个患者完整组织的时程变化有关。语音能力与左侧颞上、角回、缘上回和弓状束区域的结构完整性以及左侧顶内沟的血液动力学进展相关。言语流畅性与运动前区域的完整性以及左侧颞中/上部、左侧中枕叶和右侧角回的血液动力学进展相关。语义表现反映了内侧腹侧颞叶状态和左侧颞中后回血液动力学延迟的结合。最后，执行能力与左侧额中/下回、右侧 Rolandic 脑回、双侧辅助运动区/中扣带回区域以及双侧丘脑/尾状核的血液动力学延迟相关。中风后，患者慢性语言能力的模式反映了大脑区域分布式网络中结构和功能完整性的组合。血液动力学变化与行为之间的相关性可能具有临床意义。
