Wnt信号通路与癌症干细胞的药理学调控
Pharmacologic Manipulation of Wnt Signaling and Cancer Stem Cells.
作者信息
Duchartre Yann, Kim Yong-Mi, Kahn Michael
机构信息
Division of Hematology and Oncology, Department of Pediatrics and Pathology, Children's Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Department of Biochemistry and Molecular Biology, Keck School of Medicine of University of Southern California, Los Angeles, CA, USA.
出版信息
Methods Mol Biol. 2017;1613:463-478. doi: 10.1007/978-1-4939-7027-8_18.
Abstract
Wnt (Wingless-related integration site)-signaling orchestrates self-renewal programs in normal somatic stem cells as well as in cancer stem cells. Aberrant Wnt signaling is associated with a wide variety of malignancies and diseases. Although our understanding has increased tremendously over the past decade, therapeutic targeting of the dysregulated Wnt pathway remains a challenge. Here we review recent preclinical and clinical therapeutic approaches to target the Wnt pathway.
摘要
Wnt（无翅相关整合位点）信号通路在正常体细胞干细胞以及癌症干细胞中协调自我更新程序。异常的Wnt信号通路与多种恶性肿瘤和疾病相关。尽管在过去十年里我们的认识有了极大提高，但对失调的Wnt通路进行治疗性靶向仍然是一项挑战。在此，我们综述了针对Wnt通路的近期临床前和临床治疗方法。
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