Sun Meng Xuan, Zhu Han Ci, Yu Yang, Yao Yan, Li Hua Yao, Feng Fu Bin, Wang Qing Yang, Liu Rui Juan, Sun Chang Gang
College of First Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250355, P.R. China.
State Key Laboratory of Quality Research in Chinese Medicine, and Faculty of Chinese Medicine, Macau University of Science and Technology, Macau 999078, P.R. China.
Int J Oncol. 2025 May;66(5). doi: 10.3892/ijo.2025.5742. Epub 2025 Mar 27.
The focus on breast cancer treatment has shifted from the cytotoxic effects of single drugs on tumor cells to multidimensional multi‑pathway synergistic intervention strategies targeting the tumor microenvironment (TME). The activation of the Wnt signaling pathway in the TME of breast cancer cells serves a key regulatory role in tissue homeostasis and is a key driver of the carcinogenic process. Modulating the crosstalk between the Wnt pathway and TME of breast cancer is key for understanding the biological behavior of breast cancer and advancing the development of novel antitumor drugs. The present review aimed to summarize the complex mechanisms of the Wnt signaling pathway in the breast cancer TME, interactions between the Wnt signaling pathway and components of the breast cancer TME and breast cancer‑associated genes, as well as the interactions between the Wnt signaling pathway and other signaling cascades at the molecular level. Furthermore, the present review aimed to highlight the unique advantages of the Wnt signaling pathway in the macro‑regulation of the TME and the current therapeutic strategies targeting the Wnt signaling pathway, their potential clinical value and future research directions in breast cancer treatment.
乳腺癌治疗的重点已从单一药物对肿瘤细胞的细胞毒性作用，转向针对肿瘤微环境（TME）的多维度多途径协同干预策略。乳腺癌细胞TME中Wnt信号通路的激活在组织稳态中起关键调节作用，并且是致癌过程的关键驱动因素。调节Wnt通路与乳腺癌TME之间的相互作用，对于理解乳腺癌的生物学行为和推进新型抗肿瘤药物的开发至关重要。本综述旨在总结Wnt信号通路在乳腺癌TME中的复杂机制、Wnt信号通路与乳腺癌TME成分及乳腺癌相关基因之间的相互作用，以及Wnt信号通路与其他信号级联在分子水平上的相互作用。此外，本综述旨在突出Wnt信号通路在TME宏观调控中的独特优势，以及目前针对Wnt信号通路的治疗策略、它们在乳腺癌治疗中的潜在临床价值和未来研究方向。
