用于预防和治疗心血管疾病的基于多酚的营养保健品：人体证据综述。
Polyphenol-based nutraceuticals for the prevention and treatment of cardiovascular disease: Review of human evidence.
作者信息
Tomé-Carneiro Joao, Visioli Francesco
机构信息
Laboratory of Functional Foods, Madrid Institute for Advanced Studies (IMDEA) - Food, CEI UAM+CSIC, Madrid, Spain.
Laboratory of Functional Foods, Madrid Institute for Advanced Studies (IMDEA) - Food, CEI UAM+CSIC, Madrid, Spain; Department of Molecular Medicine, University of Padova, Viale G. Colombo 3, 35121 Padova, Italy .
出版信息
Phytomedicine. 2016 Oct 15;23(11):1145-74. doi: 10.1016/j.phymed.2015.10.018. Epub 2015 Dec 12.
BACKGROUND
In addition to prescription drugs, nutraceuticals/functional foods/medical foods are being increasingly added as adjunct treatment of cardiovascular disease (CVD), even though most of them have been exclusively studied in vitro.
HYPOTHESIS/PURPOSE: We review the available evidence (focusing on when the amount of polyphenols' intake was measured) coming from randomized controlled trials (RCTs) of (poly)phenol-based supplements.
CONCLUSION
We conclude that (poly)phenol-based nutraceuticals and functional foods might be indeed used as adjunct therapy of CVD, but additional long-term RCTs with adequate numerosity and with clinically relevant end points are needed to provide unequivocal evidence of their clinical usefulness.
背景
除了处方药外，营养保健品/功能性食品/医用食品越来越多地被用作心血管疾病（CVD）的辅助治疗，尽管其中大多数仅在体外进行了研究。
假设/目的：我们回顾了来自基于（多）酚类补充剂的随机对照试验（RCT）的现有证据（重点关注测量多酚摄入量的时间）。
结论
我们得出结论，基于（多）酚类的营养保健品和功能性食品可能确实可作为CVD的辅助治疗，但需要更多长期、足够数量且具有临床相关终点的RCT来提供其临床效用的确切证据。
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