Department of Basic Medical Sciences, Neuroscience and Sensory Organs, University of Bari, Policlinico, Piazza G. Cesare 11-70124 Bari, Italy.
Can J Physiol Pharmacol. 2013 Jun;91(6):387-96. doi: 10.1139/cjpp-2012-0307. Epub 2013 Apr 12.
In Western societies, the incidence of diet-related diseases is progressively increasing due to greater availability of hypercaloric food and a sedentary lifestyle. Obesity, diabetes, atherosclerosis, and neurodegeneration are major diet-related pathologies that share a common pathogenic denominator of low-grade inflammation. Functional foods and nutraceuticals may represent a novel therapeutic approach to prevent or attenuate diet-related disease in view of their ability to exert anti-inflammatory responses. In particular, activation of intestinal T regulatory cells and homeostatic regulation of the gut microbiota have the potential to reduce low-grade inflammation in diet-related diseases. In this review, clinical applications of polyphenol-rich functional foods and nutraceuticals in postprandial inflammation, obesity, and ageing will be discussed. We have placed special emphasis on polyphenols since they are broadly distributed in plants.
在西方社会，由于高热量食物的供应增加和久坐不动的生活方式，与饮食相关的疾病发病率正在逐渐上升。肥胖、糖尿病、动脉粥样硬化和神经退行性变是主要的与饮食相关的病理，它们都具有低度炎症这一共同的致病因素。鉴于其发挥抗炎反应的能力，功能性食品和营养保健品可能代表一种预防或减轻与饮食相关疾病的新的治疗方法。具体来说，肠道 T 调节细胞的激活和肠道微生物组的稳态调节有可能减轻与饮食相关疾病中的低度炎症。在这篇综述中，将讨论富含多酚的功能性食品和营养保健品在后肠炎症、肥胖和衰老中的临床应用。我们特别强调了多酚，因为它们广泛存在于植物中。
