YKL-40作为囊性纤维化患者严重肺部疾病的标志物。
YKL-40 as marker of severe lung disease in cystic fibrosis patients.
作者信息
Leonardi Salvatore, Parisi Giuseppe Fabio, Capizzi Antonino, Manti Sara, Cuppari Caterina, Scuderi Maria Grazia, Rotolo Novella, Lanzafame Angela, Musumeci Maria, Salpietro Carmelo
机构信息
Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy.
Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy.
出版信息
J Cyst Fibros. 2016 Sep;15(5):583-6. doi: 10.1016/j.jcf.2015.12.020. Epub 2016 Jan 8.
BACKGROUND
YKL-40 is a chitinase-like protein present in serum of healthy subjects and its levels are increased in several human inflammatory diseases. The aim of this study was to evaluate the levels of both serum and sputum YKL-40 in cystic fibrosis (CF) patients.
METHODS
Serum and sputum YKL-40 levels were measured in a cohort of twenty-eight patients with a diagnosis of CF and twenty healthy controls.
RESULTS
Serum YKL-40 levels were significantly higher in CF patients (88.8±56.7 vs 18.6±2.9ng/ml, P<0.001), as well as sputum YKL-40 levels (138.5±132.7 vs 28.2±24.34, P<0.001) than in healthy controls. Serum YKL-40 levels were closely related to YKL-40 levels assessed in sputum samples (r=0.71; P<0.01).
CONCLUSIONS
YKL-40 is elevated in CF patients and is further elevated during severe exacerbations. Longitudinal studies in infant are needed to establish its role in disease pathogenesis.
背景
YKL - 40是一种存在于健康受试者血清中的几丁质酶样蛋白，其水平在多种人类炎症性疾病中升高。本研究的目的是评估囊性纤维化（CF）患者血清和痰液中YKL - 40的水平。
方法
对一组28例诊断为CF的患者和20名健康对照者测量血清和痰液中YKL - 40水平。
结果
CF患者血清YKL - 40水平（88.8±56.7 vs 18.6±2.9ng/ml，P<0.001）以及痰液YKL - 40水平（138.5±132.7 vs 28.2±24.34，P<0.001）均显著高于健康对照者。血清YKL - 40水平与痰液样本中评估的YKL - 40水平密切相关（r = 0.71；P<0.01）。
结论
CF患者中YKL - 40升高，在严重病情加重期间进一步升高。需要对婴儿进行纵向研究以确定其在疾病发病机制中的作用。
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