具有光热特性的电活性聚合物纳米颗粒。
Electroactive Polymer Nanoparticles Exhibiting Photothermal Properties.
作者信息
Cantu Travis, Rodier Bradley, Iszard Zachary, Kilian Alissa, Pattani Varun, Walsh Kyle, Weber Katharina, Tunnell James, Betancourt Tania, Irvin Jennifer
机构信息
Materials Science, Engineering, and Commercialization Program, Texas State University.
Department of Chemistry and Biochemistry, Texas State University.
出版信息
J Vis Exp. 2016 Jan 8(107):53631. doi: 10.3791/53631.
A method for the synthesis of electroactive polymers is demonstrated, starting with the synthesis of extended conjugation monomers using a three-step process that finishes with Negishi coupling. Negishi coupling is a cross-coupling process in which a chemical precursor is first lithiated, followed by transmetallation with ZnCl2. The resultant organozinc compound can be coupled to a dibrominated aromatic precursor to give the conjugated monomer. Polymer films can be prepared via electropolymerization of the monomer and characterized using cyclic voltammetry and ultraviolet-visible-near infrared (UV-Vis-NIR) spectroscopy. Nanoparticles (NPs) are prepared via emulsion polymerization of the monomer using a two-surfactant system to yield an aqueous dispersion of the polymer NPs. The NPs are characterized using dynamic light scattering, electron microscopy, and UV-Vis-NIR-spectroscopy. Cytocompatibility of NPs is investigated using the cell viability assay. Finally, the NP suspensions are irradiated with a NIR laser to determine their effectiveness as potential materials for photothermal therapy (PTT).
展示了一种合成电活性聚合物的方法，该方法从使用三步法合成具有扩展共轭的单体开始，最终通过根岸偶联反应完成。根岸偶联是一种交叉偶联过程，其中首先将化学前体锂化，然后与ZnCl2进行金属转移反应。所得的有机锌化合物可与二溴化芳族前体偶联，得到共轭单体。聚合物薄膜可通过单体的电聚合制备，并使用循环伏安法和紫外-可见-近红外（UV-Vis-NIR）光谱进行表征。纳米颗粒（NPs）通过使用双表面活性剂体系对单体进行乳液聚合制备，以得到聚合物纳米颗粒的水分散体。使用动态光散射、电子显微镜和UV-Vis-NIR光谱对纳米颗粒进行表征。使用细胞活力测定法研究纳米颗粒的细胞相容性。最后，用近红外激光照射纳米颗粒悬浮液，以确定它们作为光热疗法（PTT）潜在材料的有效性。
Zotero 插件