Pulikkotil S J, Toh C G, Mohandas K, Leong Kvg
School of Dentistry, International Medical University, Kuala Lumpur, Malaysia.
Department of Microbiology, Faculty of Medicine, Malaysian Allied Health Science University (MAHSA), Kuala Lumpur, Malaysia.
Aust Dent J. 2016 Dec;61(4):440-445. doi: 10.1111/adj.12409.
A randomized split-mouth controlled clinical trial was conducted to evaluate the efficacy of photodynamic therapy (PDT) in reducing Aggregatibacter actinomycetemcomitans (Aa) in periodontitis patients.
Twenty patients with periodontitis were recruited for the trial. Following random allocation of either quadrants of the selected jaw to test or control treatment, conventional non-surgical periodontal therapy (NSPT) was performed. In addition, the test side received adjunct photodynamic therapy. Probing depth (PD), clinical attachment level, bleeding on probing (BoP) and plaque scores (PS%) were recorded at phase 0 (baseline), phase 1 (immediately after NSPT), phase 2 (7 days following NSPT), phase 3 (1 month following NSPT) and phase 4 (3 months following NSPT). Subgingival plaque samples for quantification of Aa by real-time polymerase chain reaction was performed at phases 0, 1, 2 and 4.
There was a significant clinical improvement at phases 3 and 4 compared with baseline while BoP reduced significantly only in the test group at phase 4. However, no difference in the quantification of Aa was detected between the groups.
Within the limits of the study, PDT adjunct to scaling and root planing does not lead to quantitative reduction of Aa in periodontitis patients.
开展了一项随机分组口内对照临床试验，以评估光动力疗法（PDT）对牙周炎患者减少伴放线聚集杆菌（Aa）的疗效。
招募20名牙周炎患者参与试验。将选定颌骨的象限随机分配至试验组或对照组进行治疗，两组均进行常规非手术牙周治疗（NSPT）。此外，试验组还接受辅助光动力疗法。在第0阶段（基线）、第1阶段（NSPT后即刻）、第2阶段（NSPT后7天）、第3阶段（NSPT后1个月）和第4阶段（NSPT后3个月）记录探诊深度（PD）、临床附着水平、探诊出血（BoP）和菌斑评分（PS%）。在第0、1、2和4阶段采集龈下菌斑样本，通过实时聚合酶链反应对Aa进行定量分析。
与基线相比，第3和第4阶段有显著的临床改善，而仅试验组在第4阶段探诊出血显著减少。然而，两组间Aa定量分析未发现差异。
在本研究范围内，刮治和根面平整联合光动力疗法不会使牙周炎患者的Aa数量减少。
