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急性淋巴细胞白血病和淋巴细胞淋巴瘤。一种疾病的两个名称(作者译)

[Acute lymphoblastic leukemia and lymphoblastic lymphoma. Two names for one disease (author's transl)].

作者信息

Winkler K, Landbeck G

出版信息

Monatsschr Kinderheilkd (1902). 1977 Jun;125(6):628-33.

PMID:267804
Abstract

Of 14 non-T-cell malignant non-Hodgkin lymphomas (mNHL) 5/14 presented with leukemic transformation of the bone marrow; in three more cases bone marrow involvement developed during an observation period of 60--200weeks. In 2/14 cases mNHL terminated the first continuous and complete remission of acute lymphoblastic leukemia (ALL). CNS involvement has been observed without preceding bone marrow involvement. Only 4/14 mNHL remained local diseases. These clinical courses as well as hematological findings and further clinical observations suggests a very close relationship between mNHL and ALL if not basic identity. With the same systemic treatment additional to local treatment, prognosis of mNHL is by no means worse but rather better than the prognosis of ALL.

摘要

在14例非T细胞恶性非霍奇金淋巴瘤(mNHL)中,5/14表现为骨髓白血病转化;另有3例在60 - 200周的观察期内出现骨髓受累。在2/14的病例中,mNHL终止了急性淋巴细胞白血病(ALL)的首次持续完全缓解。观察到中枢神经系统受累而无先前的骨髓受累情况。仅4/14的mNHL仍为局限性疾病。这些临床病程以及血液学检查结果和进一步的临床观察表明,mNHL与ALL之间存在非常密切的关系,甚至可能本质相同。采用局部治疗外加相同的全身治疗,mNHL的预后绝不是更差,而是比ALL的预后更好。

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