银屑病：幕后故事。

Psoriasis: Behind the scenes.

作者信息

Furue Masutaka, Kadono Takafumi

机构信息

Department of Dermatology, Kyushu University, Fukuoka, Japan.

Department of Dermatology, St Marianna University School of Medicine, Kawasaki, Japan.

出版信息

J Dermatol. 2016 Jan;43(1):4-8. doi: 10.1111/1346-8138.13186.

DOI:10.1111/1346-8138.13186

PMID:26782000

Abstract

Psoriasis is a chronic inflammatory skin disease characterized by a significant deterioration in the quality of life of affected individuals. Notably, psoriasis is significantly associated with cardiovascular and metabolic syndrome and other autoimmune disorders. Recent progress in biologic therapies has revealed the fundamental role of tumor necrosis factor-α, interleukin (IL)-23 and the IL-17A axis together with aberrant overproduction of epidermal IL-36γ in the pathogenesis of psoriasis. This review provides an update on the clinical, pathological and therapeutic advancements involving psoriasis.

摘要

银屑病是一种慢性炎症性皮肤病，其特征是患者的生活质量显著下降。值得注意的是，银屑病与心血管和代谢综合征以及其他自身免疫性疾病密切相关。生物疗法的最新进展揭示了肿瘤坏死因子-α、白细胞介素（IL）-23和IL-17A轴以及表皮IL-36γ的异常过度产生在银屑病发病机制中的重要作用。本文综述了银屑病在临床、病理和治疗方面的进展。