Yan L, Hu R, Tu S, Cheng W J, Zheng Q, Wang J W, Kan W S, Ren Y J
Department of Reparative and Reconstructive Surgery of Orthopedics, Puai Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Genet Mol Res. 2015 Dec 29;14(4):19225-32. doi: 10.4238/2015.December.29.32.
Osteoporosis is a common disease in the aging population and studies have shown that interleukin-6 (IL-6) is potentially implicated in its pathogenesis. This study was designed to assess the association between the IL-6 gene -634C/G polymorphism and osteoporosis. PubMed, Embase, China National Knowledge Infrastructure, and Wanfang databases were searched for eligible studies published up to and including December 2014 in English or Chinese. Meta-analysis was conducted by the RevMan5.2 software. Weighted mean difference and 95% confidence interval (95%CI) were calculated by a fixed-effect or random-effect model. Bone mineral density (BMD) was regarded as the assessment index. As a result, a total of four articles with 3068 subjects were included. Differences in BMD between the CC and GG genotypes were 0.03 g/cm(2) (95%CI = 0.01 to 0.05) at total body, 0.01 g/cm(2) (95%CI = 0.00 to 0.03) at femoral neck, and 0.03 g/cm(2) (95%CI = 0.00 to 0.06) at the lumbar spine (P < 0.05). For the CG versus GG genotypes, the differences in BMD were 0.03 g/cm(2) (95%CI = 0.02 to 0.05) at total body and 0.02 g/cm(2) (95%CI = 0.00 to 0.03 at the femoral neck (P < 0.05). For the CC versus CG genotypes, the differences in BMD were not significant (P > 0.05). In conclusion, the GG genotype of the -634C/G polymorphism in IL-6 appears to play a role in reducing BMD, which affects normal bone metabolism and leads to osteoporosis.
骨质疏松症是老年人群中的常见疾病，研究表明白细胞介素-6（IL-6）可能与其发病机制有关。本研究旨在评估IL-6基因-634C/G多态性与骨质疏松症之间的关联。检索了PubMed、Embase、中国知网和万方数据库，查找截至2014年12月（含）发表的英文或中文合格研究。使用RevMan5.2软件进行荟萃分析。采用固定效应或随机效应模型计算加权平均差和95%置信区间（95%CI）。将骨密度（BMD）作为评估指标。结果，共纳入4篇文章，涉及3068名受试者。CC和GG基因型在全身的BMD差异为0.03g/cm²（95%CI = 0.01至0.05），在股骨颈为0.01g/cm²（95%CI = 0.00至0.03），在腰椎为0.03g/cm²（95%CI = 0.00至0.06）（P < 0.05）。对于CG与GG基因型，全身的BMD差异为0.03g/cm²（95%CI = 0.02至0.05），在股骨颈为0.02g/cm²（95%CI = 0.00至0.03）（P < 0.05）。对于CC与CG基因型，BMD差异无统计学意义（P > 0.05）。总之，IL-6基因-634C/G多态性的GG基因型似乎在降低BMD方面起作用，这影响正常骨代谢并导致骨质疏松症。
