Institute of Stomatology, Nanjing Medical University, 136 Hanzhong Road, Nanjing, 210029, Jiangsu, China.
J Bone Miner Metab. 2014 Mar;32(2):167-73. doi: 10.1007/s00774-013-0477-2. Epub 2013 Jun 13.
Functional polymorphisms in the promoter region of interleukin-6 (IL-6) are known to be involved in bone mineral density (BMD) and the development of osteoporosis, but the reported results have been inconsistent. Using the meta-analysis approach, the present study is designed to provide a relatively comprehensive picture of the relationship between bone mineral density (BMD) or osteoporosis and polymorphisms in the promoter region of IL-6 (rs1800795 and rs1800796). The difference of bone mineral density (BMD) values between genotypes was examined by mean difference and 95 % confidence intervals (CIs). Association between IL-6 polymorphism and clinical osteoporosis was evaluated by pooled odds ratios (ORs) and 95 % CIs. A total of 13 articles with 11,499 subjects were included in the present study. For -174 (rs1800795), we found that individuals with the G/G genotype had a significantly lower BMD value than those with C/C genotype at femoral neck (0.02 g/cm(2), 95 % CI 0.00-0.03) (p = 0.04) and distal radius (0.01 g/cm(2), 95 %CI 0.01-0.01) (p < 0.0001). However, we did not find a statistically significant difference of BMD at the spine. When analysis was limited to postmenopausal women, similar results were obtained. We further found that the C/C genotype was associated with a reduced risk of osteoporosis compared to G/G genotype, and the pooled OR was 0.72 (95 % CI 0.54-0.95, p = 0.02). In addition, a significant relationship was found between G-634C (rs1800796) polymorphism and distal radius BMD (CC vs. GG: 0.02 g/cm(2), 95 % CI 0.01-0.03; GC vs. GG: 0.02 g/cm(2), 95 % CI 0.00-0.03) in the Asian population. These findings suggest that the CC genotype of IL-6 G-174C polymorphism may be associated with high BMD at femoral neck and distal radius and decreased risk of osteoporosis in the Caucasian population whereas G-634C polymorphism was associated with distal radius BMD in Asians.
功能多态性在白细胞介素-6（IL-6）启动子区域被认为是参与骨密度（BMD）和骨质疏松症的发展，但报告的结果一直不一致。使用荟萃分析方法，本研究旨在提供一个相对全面的关系的骨密度（BMD）或骨质疏松症和多态性在白细胞介素-6（IL-6）的启动子区域（rs1800795和rs1800796）。骨密度（BMD）值之间的基因型差异通过均数差和 95%置信区间（CI）来检查。IL-6 多态性与临床骨质疏松症的相关性通过合并优势比（ORs）和 95%CI 来评估。共有 13 篇文章，11499 例患者纳入本研究。对于-174（rs1800795），我们发现与 C/C 基因型相比，G/G 基因型的个体在股骨颈（0.02g/cm2，95%CI 0.00-0.03）（p=0.04）和桡骨远端（0.01g/cm2，95%CI 0.01-0.01）（p<0.0001）的 BMD 值明显降低。然而，我们没有发现脊柱 BMD 有统计学意义的差异。当分析仅限于绝经后妇女时，得到了类似的结果。我们还发现，与 G/G 基因型相比，C/C 基因型与骨质疏松症的风险降低有关，合并 OR 为 0.72（95%CI 0.54-0.95，p=0.02）。此外，我们还发现 G-634C（rs1800796）多态性与桡骨远端 BMD 之间存在显著关系（CC 与 GG：0.02g/cm2，95%CI 0.01-0.03；GC 与 GG：0.02g/cm2，95%CI 0.00-0.03）。这些结果表明，IL-6 G-174C 多态性的 CC 基因型可能与股骨颈和桡骨远端的高 BMD 以及白种人群骨质疏松症的风险降低有关，而 G-634C 多态性与亚洲人的桡骨远端 BMD 有关。
