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极低频脉冲磁场对链脲佐菌素诱导糖尿病大鼠糖尿病肾病的影响。

Effects of extremely low frequency pulsed magnetic fields on diabetic nephropathy in streptozotocin-treated rats.

作者信息

Li Feijiang, Lei Tao, Xie Kangning, Wu Xiaoming, Tang Chi, Jiang Maogang, Liu Juan, Luo Erping, Shen Guanghao

机构信息

School of Biomedical Engineering, Fourth Military Medical University, Xi'an, China.

出版信息

Biomed Eng Online. 2016 Jan 19;15:8. doi: 10.1186/s12938-015-0121-6.

DOI:10.1186/s12938-015-0121-6
PMID:26786255
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4717615/
Abstract

BACKGROUND

Extremely low frequency pulsed magnetic fields (ELFPMF) have been shown to induce Faraday currents and measurable effects on biological systems. A kind of very high frequency electromagnetic field was reported that it improved the symptoms of diabetic nephropathy (DN) which is a major complication of diabetes. However, few studies have examined the effects of ELFPMF DN at the present. The present study was designed to investigate the effects of ELFPMF on DN in streptozotocin (STZ)-induced type 1 diabetic rats.

METHODS

Adult male SD rats were randomly divided into three weight-matched groups: Control (non-diabetic rats without DN), DN + ELFPMF (diabetic rats with DN exposed to ELFPMF, 8 h/days, 6 weeks) and DN (diabetic rats with DN exposed to sham ELFPMF). Renal morphology was examined by light and electron microscopy, vascular endothelial growth factor (VEGF)-A and connective tissue growth factor (CTGF) were measured by enzyme linked immune sorbent assay.

RESULTS

After 6 weeks' ELFPMF exposure, alterations of hyperglycemia and weight loss in STZ-treated rats with DN were not found, while both positive and negative effects of ELFPMF on the development of DN in diabetic rats were observed. The positive one was that ELFPMF exposure attenuated the pathological alterations in renal structure observed in STZ-treated rats with DN, which were demonstrated by slighter glomerular and tubule-interstitial lesions examined by light microscopy and slighter damage to glomerular basement membrane and podocyte foot processes examined by electron microscopy. And then, the negative one was that ELFPMF stimulation statistically significantly decreased renal expression of VEGF-A and statistically significantly increased renal expression of CTGF in diabetic rats with DN, which might partially aggravate the symptoms of DN.

CONCLUSION

Both positive and negative effects of ELFPMF on the development of DN in diabetic rats were observed. The positive effect induced by ELFPMF might play a dominant role in the procession of DN in diabetic rats, and it is suggested that the positive effect should be derived from the correction of pathogenic diabetes-induced mediators.

摘要

背景

极低频脉冲磁场（ELFPMF）已被证明可诱导法拉第电流并对生物系统产生可测量的影响。据报道，一种非常高频的电磁场可改善糖尿病肾病（DN）的症状，糖尿病肾病是糖尿病的主要并发症。然而，目前很少有研究探讨ELFPMF对DN的影响。本研究旨在探讨ELFPMF对链脲佐菌素（STZ）诱导的1型糖尿病大鼠DN的影响。

方法

成年雄性SD大鼠随机分为三个体重匹配组：对照组（无DN的非糖尿病大鼠）、DN + ELFPMF组（暴露于ELFPMF的DN糖尿病大鼠，8小时/天，共6周）和DN组（暴露于假ELFPMF的DN糖尿病大鼠）。通过光镜和电镜检查肾脏形态，采用酶联免疫吸附测定法测量血管内皮生长因子（VEGF）-A和结缔组织生长因子（CTGF）。

结果

ELFPMF暴露6周后，未发现STZ诱导的DN大鼠出现高血糖和体重减轻的改变，同时观察到ELFPMF对糖尿病大鼠DN发展的正负两种影响。积极的影响是，ELFPMF暴露减轻了STZ诱导的DN大鼠肾脏结构的病理改变光镜检查显示肾小球和肾小管间质病变较轻，电镜检查显示肾小球基底膜和足细胞足突损伤较轻。消极的影响是，ELFPMF刺激使DN糖尿病大鼠肾脏VEGF-A表达统计学显著降低，CTGF表达统计学显著升高，这可能部分加重DN症状。

结论

观察到ELFPMF对糖尿病大鼠DN发展的正负两种影响。ELFPMF诱导的积极影响可能在糖尿病大鼠DN进程中起主导作用，提示这种积极影响应源于对糖尿病诱导的致病介质的纠正。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7732/4717615/d072e7e46367/12938_2015_121_Fig7_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7732/4717615/febc6fd993bd/12938_2015_121_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7732/4717615/d072e7e46367/12938_2015_121_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7732/4717615/fd271d9090ed/12938_2015_121_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7732/4717615/f8641cb977e5/12938_2015_121_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7732/4717615/a9f5bd82729c/12938_2015_121_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7732/4717615/84d7c2ae1d79/12938_2015_121_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7732/4717615/9c93921ec16b/12938_2015_121_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7732/4717615/febc6fd993bd/12938_2015_121_Fig6_HTML.jpg
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