Nørrelund N, Christiansen L V, Plantener S
Ugeskr Laeger. 1989 Sep 18;151(38):2436-8.
To compare the effect of tolfenamic acid and paracetamol in acute migraine, 149 patients participated in a double-blind controlled, multipractice study. 116 patients completed both treatments. The patients were asked to evaluate the two drugs in terms of the following parametres: 1) intensity of headache after three hours: as usual or less, 2) necessity of further medicine after three hours, 3) assessment of test medicine regarding the effect on strength, duration, and other inconveniences connected with the headache, 4) possible side effect connected with test medicine, and how these were experienced. After both forms of treatment, the patients were asked to give an overall judgement of the medicine, which had the best effect. No statistically significant difference was observed between the effect of 400 mg tolfenamic acid and 1 g paracetamol as to the five test parametres when using parametric or non-parametric statistics with a significance level of 5%. However, tolfenamic acid was numerically better than paracetamol with regard to headache after three hours, necessity of further medicine, judgement of attacks, and preference.
为比较托芬那酸和对乙酰氨基酚治疗急性偏头痛的效果，149名患者参与了一项双盲对照、多机构研究。116名患者完成了两种治疗。要求患者根据以下参数对两种药物进行评估：1）三小时后头痛的强度：与往常相同或减轻；2）三小时后是否需要进一步用药；3）对试验药物在缓解头痛的强度、持续时间及其他不适方面的评价；4）试验药物可能的副作用及患者的感受。两种治疗方式结束后，要求患者对效果最佳的药物给出总体评价。当显著性水平为5%，使用参数或非参数统计方法时，400毫克托芬那酸和1克对乙酰氨基酚在五项测试参数上的效果未观察到统计学显著差异。然而，在三小时后的头痛、进一步用药的必要性、发作的判断和偏好方面，托芬那酸在数值上优于对乙酰氨基酚。
