de-Faria Felipe Meira, Almeida Ana Cristina Alves, Luiz-Ferreira Anderson, Takayama Christiane, Dunder Ricardo José, da Silva Marcelo Aparecido, Salvador Marcos José, Abdelnur Patrícia Verardi, Eberlin Marcos Nogueira, Vilegas Wagner, Toma Walber, Souza-Brito Alba Regina Monteiro
Departamento de Farmacologia, Faculdade de Ciências Médicas, UNICAMP, 13083-970 Campinas, SP, Brazil.
ScientificWorldJournal. 2012;2012:327071. doi: 10.1100/2012/327071. Epub 2012 Apr 30.
Rhizophora mangle, the red mangrove, has long been known as a traditional medicine. Its bark has been used as astringent, antiseptic, hemostatic, with antifungic and antiulcerogenic properties. In this paper, we aimed to evaluate the antioxidant properties of a buthanolic fraction of the R. mangle bark extract (RM) against experimental gastric ulcer in rats. Unib-Wh rats received pretreatment of R. mangle after the induction of gastric injury with absolute ethanol and ischemia-reperfusion. Gastric tissues from both methods were prepared to the enzymatic assays, the levels of sulfhydril compounds (GSH), lipid peroxides (LPO), and the activities of glutathione reductase (GR), glutathione peroxidase (GPx), superoxide dismutase (SOD) and myeloperoxidase (MPO) were measured. The RM protected the gastric mucosa in both methods used, ethanol-induced gastric ulcer and ischemia-reperfusion, probably, by modulating the activities of the enzymes SOD, GPx, and GR and increasing or maintaining the levels of GSH; in addition, LPO levels were reduced. The results suggest that the RM antioxidant activity leads to tissue protection; thus one of the antiulcer mechanisms present on the pharmacological effects of R. mangle is the antioxidant property.
红树植物红树，长期以来一直被视为一种传统药物。其树皮具有收敛、防腐、止血作用，还具备抗真菌和抗溃疡特性。在本文中，我们旨在评估红树树皮提取物（RM）的丁醇馏分对大鼠实验性胃溃疡的抗氧化特性。用无水乙醇诱导胃损伤并进行缺血再灌注后，将Wistar大鼠分为几组并给予红树预处理。对两种方法诱导的胃损伤大鼠的胃组织进行酶学分析，测定巯基化合物（GSH）、脂质过氧化物（LPO）水平，以及谷胱甘肽还原酶（GR）、谷胱甘肽过氧化物酶（GPx）、超氧化物歧化酶（SOD）和髓过氧化物酶（MPO）的活性。RM对乙醇诱导的胃溃疡和缺血再灌注这两种方法诱导的胃损伤均有保护作用，可能是通过调节SOD、GPx和GR的活性以及提高或维持GSH水平实现的；此外，LPO水平降低。结果表明，RM的抗氧化活性可导致组织保护；因此，红树药理作用中存在的抗溃疡机制之一是抗氧化特性。
