妊娠期抗肾小球基底膜病：经血浆置换、血液透析及类固醇治疗后急性肾衰竭得以缓解
Anti-GBM Disease in Pregnancy: Acute Renal Failure Resolved After Plasma Exchange, Hemodialysis, and Steroids.
作者信息
Adnan Mohammed Muqeet, Morton Jordan, Hashmi Syed, Abdul Mujeeb Sufyan, Kern William, Cowley Benjamin D
机构信息
University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
University of Illinois at Chicago, IL, USA.
出版信息
J Investig Med High Impact Case Rep. 2015 Dec 31;4(1):2324709615624232. doi: 10.1177/2324709615624232. eCollection 2016 Jan-Mar.
Antiglomerular basement membrane (GBM) disease presenting during pregnancy is uncommon. We present a case of a pregnant female who presented with acute renal failure requiring dialysis due to anti-GBM disease. She responded well to plasma exchange, high-dose steroids, and hemodialysis. Cyclophosphamide was discussed but not given at the patient's request due to concerns for the well-being of the fetus. Unfortunately, she suffered a spontaneous abortion in her eighth week of pregnancy. Subsequently, she had progressive improvement in her renal function and became hemodialysis independent at 2 weeks after diagnosis. Her renal function returned to baseline 3 months after diagnosis. We present this case in detail and review the literature regarding anti-GBM disease in pregnancy.
妊娠期间出现的抗肾小球基底膜（GBM）病并不常见。我们报告一例妊娠女性，因抗GBM病出现急性肾衰竭，需要进行透析治疗。她对血浆置换、大剂量类固醇和血液透析反应良好。曾讨论使用环磷酰胺，但由于担心胎儿健康，根据患者要求未予使用。不幸的是，她在妊娠第8周时发生自然流产。随后，她的肾功能逐渐改善，诊断后2周不再依赖血液透析。诊断后3个月，她的肾功能恢复至基线水平。我们详细介绍该病例，并复习妊娠期间抗GBM病的相关文献。
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