Latasch L, Lüders S
Department of Anesthesia, BG-Traumacenter (BGU), Frankfurt am Main, West Germany.
Acta Anaesthesiol Belg. 1989;40(2):113-9.
60 patients (ASA class I-II) undergoing knee arthrotomy received in a double blind fashion, a transdermal drug delivery system, containing either fentanyl (delivery rate of 75 micrograms/hour)--Fentanyl TTS--or placebo. The system remained in place for 24 hours. Even when piritramid was added as escape analgesia, all respiratory and hemodynamic parameters, as well as blood gas analysis showed no statistical significant difference between both groups (fentanyl or placebo). One patient had evidence of a beginning respiratory depression, but no specific therapy was needed. No significant side effects were seen. Concerning escape medication, a highly statistically significant difference in favour of Fentanyl TTS was found (p less than 0.001).
60例接受膝关节切开术的患者（ASA分级I-II级）以双盲方式接受一种经皮给药系统，该系统含芬太尼（释放速率为75微克/小时）——芬太尼透皮贴剂（Fentanyl TTS）或安慰剂。该系统持续贴敷24小时。即使添加了匹米诺定作为补救镇痛，两组（芬太尼组或安慰剂组）的所有呼吸和血流动力学参数以及血气分析均未显示出统计学上的显著差异。1例患者有开始出现呼吸抑制的迹象，但无需特殊治疗。未观察到明显的副作用。关于补救用药，发现芬太尼透皮贴剂组具有高度统计学显著优势（p<0.001）。
