El Mahdy Korah T, Abd Elfatah Badr E, Mohamed Emara M, Ahmed Samy Kohla M, Gamal Saad Michael G
Internal Medicine Department, Faculty of Medicine, Menoufia University, Shebin ElKom, Egypt.
Medical Biochemistry Department, Faculty of Medicine, Menoufia University, Shebin ElKom, Egypt.
Andrologia. 2016 Nov;48(9):948-955. doi: 10.1111/and.12536. Epub 2016 Jan 21.
Males have higher incidence of hepatocellular carcinoma (HCC) than females. Sex hormones may be a risk factor. The aim was to determine the levels of sex hormones in male and female patients with HCC and cirrhosis versus controls and its possible relationship with HCC. This study was conducted on 90 subjects divided into 40 patients with HCC, 30 patients with liver cirrhosis and 20 apparently healthy subjects complete blood picture, liver function tests. Determination of AFP levels and hormonal assay of oestrogen, progesterone, total testosterone, prolactin, FSH and LH were performed on all subjects. Total testosterone levels were significantly decreased in the two patients groups compared with controls. While oestrogen levels were significantly decreased in the HCC group in comparison with other two groups, prolactin levels were significantly decreased in the HCC group compared with the liver cirrhosis group and increased in the liver cirrhosis group when compared to controls. FSH and LH levels were significantly increased in the HCC group when compared to controls. There is no significant correlation between sex hormones assay and both the size of HCC and degree of cirrhosis in both patient groups. It is concluded that there is no strong relation between sex hormones and HCC when the study was carried out on the levels of sex hormones in patients with HCC.
男性肝细胞癌（HCC）的发病率高于女性。性激素可能是一个危险因素。目的是确定HCC和肝硬化男性及女性患者与对照组中性激素水平及其与HCC的可能关系。本研究对90名受试者进行，分为40例HCC患者、30例肝硬化患者和20名明显健康的受试者，进行全血细胞计数、肝功能检查。对所有受试者进行甲胎蛋白（AFP）水平测定以及雌激素、孕酮、总睾酮、催乳素、促卵泡激素（FSH）和促黄体生成素（LH）的激素测定。与对照组相比，两个患者组的总睾酮水平显著降低。与其他两组相比，HCC组的雌激素水平显著降低，与肝硬化组相比，HCC组的催乳素水平显著降低，与对照组相比，肝硬化组的催乳素水平升高。与对照组相比，HCC组的FSH和LH水平显著升高。两个患者组中性激素测定与HCC大小和肝硬化程度之间均无显著相关性。结论是，在对HCC患者的性激素水平进行研究时，性激素与HCC之间没有密切关系。
