Heil Emily L, Johnson J Kristie
Department of Pharmacy, University of Maryland Medical Center, Baltimore, Maryland, USA.
Department of Pathology, University of Maryland School of Medicine, Baltimore, Maryland, USA
J Clin Microbiol. 2016 Apr;54(4):840-4. doi: 10.1128/JCM.02424-15. Epub 2016 Jan 20.
In 2010, the Clinical and Laboratory Standards Institute (CLSI) lowered the MIC breakpoints for many beta-lactam antibiotics to enhance detection of known resistance amongEnterobacteriaceae The decision to implement these new breakpoints, including the changes announced in both 2010 and 2014, can have a significant impact on both microbiology laboratories and antimicrobial stewardship programs. In this commentary, we discuss the changes and how implementation of these updated CLSI breakpoints requires partnership between antimicrobial stewardship programs and the microbiology laboratory, including data on the impact that the changes had on antibiotic usage at our own institution.
2010年,临床和实验室标准协会(CLSI)降低了多种β-内酰胺类抗生素的最低抑菌浓度(MIC)折点,以加强对肠杆菌科细菌已知耐药性的检测。实施这些新折点的决定,包括2010年和2014年宣布的变化,可能会对微生物实验室和抗菌药物管理计划产生重大影响。在本评论中,我们讨论了这些变化,以及实施这些更新后的CLSI折点如何需要抗菌药物管理计划与微生物实验室之间的合作,包括关于这些变化对我们自己机构抗生素使用影响的数据。