Amo Gemma, García-Menaya Jesús, Campo Paloma, Cordobés Concepción, Plaza Serón M Carmen, Ayuso Pedro, Esguevillas Gara, Blanca Miguel, Agúndez Jose A G, García-Martín Elena
Department of Pharmacology, Universidad de Extremadura, Cáceres, Spain.
Allergy Service, University Hospital Infanta Cristina, Badajoz, Spain.
Sci Rep. 2016 Jan 21;6:19724. doi: 10.1038/srep19724.
Allergic rhinitis is associated with elevated serum IgE levels. IgE response is mediated by the high-affinity IgE receptor (FcεRI), which is polymorphic. Studies analyzing the association between allergic rhinitis and FcεRI variants have been conducted with controversial results. The objective of this study is to analyze, in 1,041 individuals, the putative clinical association of allergic rhinitis with common polymorphisms in FcεRI subunits genes. These SNPs included FECR1A rs2494262, rs2427837 and rs2251746; FECR1B rs1441586, rs569108 and rs512555; FCER1G rs11587213, rs2070901 and rs11421. Statistically significant differences were observed for the FCER1B rs569108 and rs512555 polymorphisms frequencies when comparing patients with allergic rhinitis without asthma and controls. The OR (95% CI) value for the 237Gly allele (rs569108) is equal to 0.26 (0.08-0.86, P = 0.017) and for the G allele (rs512555) it is equal to 0.27 (0.08-0.88, P = 0.020). These two SNPs are linked (D' = 1.0, LOD = 56.05). Also observed was a statistically significant trend towards lower IgE values among allergic rhinitis patients with variant alleles for both SNPs. In conclusion, in patients with allergic rhinitis without asthma, the FCER1B rs569108 and rs512555 polymorphisms are associated with increased risk of developing allergic rhinitis and with lower IgE levels.
变应性鼻炎与血清IgE水平升高有关。IgE反应由高亲和力IgE受体（FcεRI）介导，该受体具有多态性。分析变应性鼻炎与FcεRI变体之间关联的研究结果存在争议。本研究的目的是在1041名个体中分析变应性鼻炎与FcεRI亚基基因常见多态性之间的假定临床关联。这些单核苷酸多态性（SNP）包括FECR1A rs2494262、rs2427837和rs2251746；FECR1B rs1441586、rs569108和rs512555；FCER1G rs11587213、rs2070901和rs11421。在比较无哮喘的变应性鼻炎患者和对照组时，观察到FCER1B rs569108和rs512555多态性频率存在统计学显著差异。237Gly等位基因（rs569108）的比值比（OR，95%可信区间）为0.26（0.08 - 0.86，P = 0.017），G等位基因（rs512555）的比值比为0.27（0.08 - 0.88，P = 0.020）。这两个SNP处于连锁状态（D' = 1.0，LOD = 56.05）。还观察到，对于这两个SNP具有变异等位基因的变应性鼻炎患者中，IgE值有统计学显著降低趋势。总之，在无哮喘的变应性鼻炎患者中，FCER1B rs569108和rs512555多态性与变应性鼻炎发病风险增加及较低的IgE水平相关。
