Sarriá Chueca A, Oliván Gonzalvo G, Lázaro Almarza A, Fleta Zaragozano J, Tosao Sánchez A, Escanero Marcén J F, Elósegui Alberdi L M, Bueno Sánchez M
Departamento de Pediatría, Facultad de Medicina, Universidad de Zaragoza.
An Esp Pediatr. 1989 Jun;30(6):447-50.
The authors present a system for the appraisal of the nutritional and inflammatory condition in patients suffering from cystic fibrosis (CF) in the phase of apparent inactivity of pulmonary infection, using a system of indices based on the quantification of some plasmatic proteins. The plasmatic appraisals of 4 visceral proteins (albumin, thyroxine-binding prealbumin, retinol-binding protein and transferrin) and, as well, of 5 proteins of the acute phase (alpha-1-acid glycoprotein, alpha-1-antitrypsin, alpha-2-macroglobulin, haptoglobin and ceruloplasmin) were obtained in a control group of 16 healthy children and in another of 14 children affected by CF. With the proteic plasmatic appraisals of the control group, the knowledge of their biological value and after a statistical-mathematical analysis, the most sensitive, specific and independent proteins were determined for evaluating the nutritional and inflammatory condition, obtaining two simple formulas which were denominated Nutritional-Inflammatory Prognostic Indices (NIPI) A and B (NIPI A = alpha-1-acid glycoprotein + haptoglobin/albumin + prealbumin; NIPI B = haptoglobin/albumin). From the analysis of the results, it can be deduced that the children with CF are affected by an inflammatory process, very probably infectious.
作者提出了一种系统，用于评估处于肺部感染明显静止期的囊性纤维化（CF）患者的营养和炎症状况，该系统基于一些血浆蛋白的定量指标。在16名健康儿童的对照组和另外14名受CF影响的儿童中，对4种内脏蛋白（白蛋白、甲状腺素结合前白蛋白、视黄醇结合蛋白和转铁蛋白）以及5种急性期蛋白（α-1-酸性糖蛋白、α-1-抗胰蛋白酶、α-2-巨球蛋白、触珠蛋白和铜蓝蛋白）进行了血浆评估。通过对照组的血浆蛋白评估，了解其生物学价值并经过统计数学分析，确定了用于评估营养和炎症状况的最敏感、特异和独立的蛋白，得出了两个简单公式，分别称为营养-炎症预后指数（NIPI）A和B（NIPI A =α-1-酸性糖蛋白+触珠蛋白/白蛋白+前白蛋白；NIPI B =触珠蛋白/白蛋白）。从结果分析可以推断，CF患儿受到炎症过程的影响，很可能是感染性炎症。
