Richard-Lenoble D, Kombila M, Martz M, Lefèvre B, Chandenier J, Gay F, Billiault X, Thérizol-Ferly M
Ann Soc Belg Med Trop. 1989 Jun;69(2):113-9.
Unknown in 1980, suspected in 1983 and scarcely present in 1984-85, Plasmodium falciparum resistance to chloroquine as studied in vivo in schoolchildren in Gabon, has strongly developed in 4 years time. In 1987-88, administration of 25 mg/kg of chloroquine leaves one strain out of four with a parasitic load greater than 10/1.000 red blood cells examined by thick drop technique. The present, unfortunately provisional attitude tends to maintain chloroquine at efficient doses for as long as the resistant strains are ethically and practically controllable. The dispersion without strict control of new and for the time being very efficient drugs might rapidly give rise to a polychemoresistance which would leave us without defence.
1980年时尚不为人知，1983年受到怀疑，1984 - 1985年几乎不存在，在加蓬学童中进行的体内研究表明，恶性疟原虫对氯喹的耐药性在4年时间里已强烈发展。在1987 - 1988年，给予25毫克/千克的氯喹后，通过厚涂片技术检查，四分之一的菌株寄生虫负荷大于每1000个红细胞中有10个。不幸的是，目前的临时态度倾向于只要耐药菌株在伦理和实际操作上可控，就维持氯喹的有效剂量。如果对新的、目前非常有效的药物不进行严格控制就加以推广，可能会迅速导致多重耐药性，使我们毫无防备。
