Hoişie S, Pencea I, Lupuşoru E, Grigoraş E, Anicăi O, Pencea D, Anton D, Uliciuc S, Stanciu V, Buzdugan R
Arch Roum Pathol Exp Microbiol. 1989 Jan-Mar;48(1):55-64.
There were investigated possible deleterious effects induced in white mice and rabbits by prolonged administration of polidin in different concentrations, as well as of polidin associated with membrane fraction of Klebsiella pneumoniae. In the experimental model used all the animals evolved normally presenting some transient blood modifications which occurred after administration of comparatively much higher doses than those usually administered in man. There were not noticed significant macroscopical and microscopical modifications at the level of the organs sampled from mice. The pregnant female mice treated along one month with doses, proportionally 1000 times higher than those used in human therapy, presented some pathological aspects, which disappeared on cessation of therapy with the biological. These animals were not affected by abortions and the experiment proved the absence of some teratogenic effects connected to polidin administration. The prolonged polidin administration also acted as an immunostimulant of the natural and acquired defense system.
研究了不同浓度的多利定以及与肺炎克雷伯菌膜部分相关的多利定长期给药对白鼠和兔子可能产生的有害影响。在所用的实验模型中，所有动物均正常发育，在给予比人类通常使用剂量高得多的剂量后出现了一些短暂的血液变化。从小鼠采集的器官水平上未观察到明显的宏观和微观变化。怀孕的雌性小鼠用比人类治疗中使用剂量高1000倍的剂量治疗一个月，出现了一些病理表现，在停止使用该生物制剂治疗后消失。这些动物未受流产影响，实验证明多利定给药不存在某些致畸作用。长期给予多利定还可作为天然和获得性防御系统的免疫刺激剂。
