Study on possible deleterious effects induced in white mice and rabbits by prolonged administration of polidin in different concentrations.

There were investigated possible deleterious effects induced in white mice and rabbits by prolonged administration of polidin in different concentrations, as well as of polidin associated with membrane fraction of Klebsiella pneumoniae. In the experimental model used all the animals evolved normally presenting some transient blood modifications which occurred after administration of comparatively much higher doses than those usually administered in man. There were not noticed significant macroscopical and microscopical modifications at the level of the organs sampled from mice. The pregnant female mice treated along one month with doses, proportionally 1000 times higher than those used in human therapy, presented some pathological aspects, which disappeared on cessation of therapy with the biological. These animals were not affected by abortions and the experiment proved the absence of some teratogenic effects connected to polidin administration. The prolonged polidin administration also acted as an immunostimulant of the natural and acquired defense system.