Wårdell Karin, Hemm-Ode Simone, Rejmstad Peter, Zsigmond Peter
Department of Biomedical Engineering, Linkx00F6;ping University, Linkx00F6;ping, Sweden.
Stereotact Funct Neurosurg. 2016;94(1):1-9. doi: 10.1159/000442894. Epub 2016 Jan 22.
Laser Doppler flowmetry (LDF) can be used to measure cerebral microcirculation in relation to stereotactic deep brain stimulation (DBS) implantations.
To investigate the microcirculation and total light intensity (TLI) corresponding to tissue grayness in DBS target regions with high-resolution LDF recordings, and to define a resolution which enables detection of small vessels.
Stereotactic LDF measurements were made prior to DBS implantation with 0.5-mm steps in the vicinity to 4 deep brain targets (STN, GPi, Vim, Zi) along 20 trajectories. The Mann-Whitney U test was used to compare the microcirculation and TLI between targets, and the measurement resolution (0.5 vs. 1 mm). The numbers of high blood flow spots along the trajectories were calculated.
There was a significant difference (p < 0.05) in microcirculation between the targets. High blood flow spots were present at 15 out of 510 positions, 7 along Vim and GPi trajectories, respectively. There was no statistical difference between resolutions even though both local blood flow and TLI peaks could appear at 0.5-mm steps.
LDF can be used for online tracking of critical regions presenting blood flow and TLI peaks, possibly relating to vessel structures and thin laminas along stereotactic trajectories.
激光多普勒血流仪（LDF）可用于测量与立体定向深部脑刺激（DBS）植入相关的脑微循环。
通过高分辨率LDF记录，研究DBS目标区域中与组织灰度相对应的微循环和总光强（TLI），并确定能够检测小血管的分辨率。
在DBS植入前，沿20条轨迹以0.5毫米的步长在4个深部脑靶点（STN、GPi、Vim、Zi）附近进行立体定向LDF测量。采用曼-惠特尼U检验比较各靶点之间的微循环和TLI，以及测量分辨率（0.5毫米与1毫米）。计算沿轨迹的高血流点数量。
各靶点之间的微循环存在显著差异（p < 0.05）。在510个位置中的15个位置出现了高血流点，其中7个分别位于Vim和GPi轨迹上。尽管局部血流和TLI峰值都可能在0.5毫米步长时出现，但分辨率之间没有统计学差异。
LDF可用于在线跟踪呈现血流和TLI峰值的关键区域，这些区域可能与沿立体定向轨迹的血管结构和薄层有关。
