Division of Epidemiology, School of Public Health, University of California, Berkeley.
Division of Epidemiology, School of Public Health, University of California, Berkeley.
Ann Epidemiol. 2016 Feb;26(2):141-145. doi: 10.1016/j.annepidem.2015.11.007. Epub 2015 Dec 12.
The purpose of the study was to examine whether birth characteristics affect the risk of rhabdomyosarcoma (RMS) in children and adolescents younger than 19 years.
A total of 722 RMS cases diagnosed at the age of 0-19 years during 1988-2011 were identified from the California Cancer Registry and matched by birth date, sex, and race to 2,888 controls using California birth records. Conditional logistic regression was used to estimate the risk of RMS associated with birth weight, gestational age, and size for gestational age.
High birth weight (odds ratio [OR]: 1.00; 95% confidence interval [CI]: 0.78-1.29) and large for gestational age (LGA; OR: 0.94, 95% CI: 0.72-1.23) were not associated with RMS risk overall. Among non-Hispanic whites, the ORs were 1.33 for high birth weight (95% CI: 0.94-1.89) and 1.17 for LGA (95% CI: 0.78-1.75); no indications of association were observed for other racial or ethnic groups (P interaction <.10). Compared with normal gestational age, preterm (<37 weeks) and post-term (>40 weeks) babies had 16%-18% lower risks of RMS overall, after adjusting for birth weight.
In the largest study to date, there was an indication of association between high birth weight, LGA, and increased RMS risk among non-Hispanic white children and adolescents, but not in other racial or ethnic groups.
本研究旨在探讨出生特征是否会影响 19 岁以下儿童和青少年患横纹肌肉瘤（RMS）的风险。
从加利福尼亚癌症登记处确定了 1988 年至 2011 年期间诊断为 0-19 岁的 722 例 RMS 病例，并通过加利福尼亚出生记录按出生日期、性别和种族与 2888 名对照进行匹配。使用条件逻辑回归来估计与出生体重、胎龄和胎儿生长大小相关的 RMS 风险。
高出生体重（比值比 [OR]：1.00；95%置信区间 [CI]：0.78-1.29）和胎儿生长过大（LGA；OR：0.94，95% CI：0.72-1.23）与总体 RMS 风险无关。在非西班牙裔白人中，高出生体重的比值比为 1.33（95%CI：0.94-1.89），LGA 的比值比为 1.17（95%CI：0.78-1.75）；其他种族或族裔群体没有观察到关联迹象（P 交互<.10）。与正常胎龄相比，早产儿（<37 周）和过期儿（>40 周）总体 RMS 风险降低 16%-18%，这是在调整出生体重后得出的结果。
在迄今为止最大的研究中，高出生体重、LGA 与非西班牙裔白人儿童和青少年 RMS 风险增加之间存在关联迹象，但在其他种族或族裔群体中没有观察到这种关联。
