Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Richard Doll Building, Old Road Campus, Oxford, OX3 7LF, UK.
National Perinatal Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Richard Doll Building, Old Road Campus, Oxford, OX3 7LF, UK.
Br J Cancer. 2020 Apr;122(8):1250-1259. doi: 10.1038/s41416-020-0760-7. Epub 2020 Feb 26.
This nationwide study investigated associations between paternal occupational exposure and childhood bone tumours and soft- tissue sarcomas.
The UK National Registry of Childhood Tumours provided cases of childhood sarcomas born and diagnosed in Great Britain, 1962-2010. Control births, unaffected by childhood cancer, were matched on sex, birth period and birth registration sub-district. Fathers' occupations were assigned to one or more of 33 exposure groups and coded for occupational social class.
We analysed 5,369 childhood sarcoma cases and 5380 controls. Total bone tumours, total soft-tissue sarcomas and the subgroups osteosarcoma, rhabdomyosarcoma and Ewing Sarcoma Family of Tumours (ESFT) were considered separately. Significant positive associations were seen between rhabdomyosarcoma and paternal exposure to EMFs (odds ratio = 1.67, CI = 1.22-2.28) and also for ESFT and textile dust (1.93, 1.01-3.63). There were putative protective effects on total bone tumours of paternal dermal exposure to hydrocarbons, metal, metal working or oil mists.
Despite the large size and freedom from bias of this study, our results should be interpreted with caution. Many significance tests were undertaken, and chance findings are to be expected. Nevertheless, our finding of associations between ESFT and paternal exposure to textile dust may support related suggestions in the literature.
本全国性研究调查了父亲职业暴露与儿童骨肿瘤和软组织肉瘤之间的关联。
英国国家儿童肿瘤登记处提供了 1962 年至 2010 年在大不列颠出生和诊断的儿童肉瘤病例。对照出生不受儿童癌症影响，按性别、出生时期和出生登记分区进行匹配。父亲的职业被分配到 33 个暴露组中的一个或多个，并按职业社会阶层进行编码。
我们分析了 5369 例儿童肉瘤病例和 5380 例对照。分别考虑了总骨肿瘤、总软组织肉瘤以及骨肉瘤、横纹肌肉瘤和尤文肉瘤家族肿瘤（ESFT）亚组。横纹肌肉瘤与父亲接触电磁场（比值比=1.67，95%置信区间=1.22-2.28）以及 ESFT 与纺织尘之间存在显著正相关。父亲接触碳氢化合物、金属、金属加工或油雾的皮肤暴露对总骨肿瘤有潜在的保护作用。
尽管这项研究规模很大且没有偏倚，但我们的结果应谨慎解释。进行了许多显著性检验，预计会出现偶然发现。然而，我们发现 ESFT 与父亲接触纺织尘之间存在关联，这可能支持文献中的相关建议。
