Herdman Michael, Hoyle Christopher K, Coles Victoria, Carroll Stuart, Devlin Nancy
Office of Health Economics, London, UK.
Office of Health Economics, London, UK.
Value Health. 2016 Jan;19(1):109-19. doi: 10.1016/j.jval.2015.10.001. Epub 2015 Nov 19.
To investigate the use of patient-reported outcomes (PROs) in pediatric populations with vaccine-preventable infectious diseases in high-income Western countries.
Systematic review of PRO use in populations younger than 18 years with any of 17 infectious diseases for which vaccines are available or in development. The search was limited to studies performed in Europe, North America, Australia, and New Zealand and published between January 1, 1990, and July 31, 2013. Searches were conducted in Scopus and PsycINFO, and reference lists were manually searched. Results are reported using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.
Of 6410 titles and abstracts and 174 full-text articles reviewed, 17 full-text articles were included for data extraction. The largest number of PRO studies was carried out in patients with anogenital warts and rotavirus gastroenteritis. No PRO studies were identified for nine conditions. A total of 24 PRO measures (12 generic and 12 disease-specific) were used in the studies reviewed. Most of the instruments used were of high quality. Proxy responses were occasionally obtained when self-report would have been feasible. No validated disease-specific instruments for children with any of the conditions studied were found.
The paucity of studies and PRO instruments to assess pediatric health status in vaccine-preventable infectious diseases, and the lack of a standardized approach to measurement, makes it difficult to capture the impact of disease and the benefit of vaccination and could potentially hinder decision making. Guidelines from relevant bodies to steer research in this area would be useful.
调查在西方高收入国家患有疫苗可预防传染病的儿科人群中患者报告结局（PROs）的使用情况。
对18岁以下患有17种现有或正在研发疫苗的传染病中任何一种的人群使用PROs的情况进行系统评价。检索限于1990年1月1日至2013年7月31日期间在欧洲、北美、澳大利亚和新西兰进行并发表的研究。在Scopus和PsycINFO中进行检索，并手动检索参考文献列表。使用系统评价和Meta分析的首选报告项目指南报告结果。
在审查的6410篇标题和摘要以及174篇全文文章中，纳入了17篇全文文章进行数据提取。关于PROs的研究数量最多的是肛门生殖器疣和轮状病毒胃肠炎患者。未发现针对9种疾病的PROs研究。在所审查的研究中总共使用了24种PRO测量方法（12种通用方法和12种疾病特异性方法）。使用的大多数工具质量较高。在可行的情况下偶尔会获得代理答复。未找到针对所研究的任何疾病儿童的经过验证的疾病特异性工具。
评估疫苗可预防传染病中儿科健康状况的研究和PRO工具匮乏，且缺乏标准化的测量方法，这使得难以了解疾病的影响和疫苗接种的益处，并可能阻碍决策。相关机构制定该领域研究的指南将很有用。
