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Rh2E2是一种新型的代谢抑制剂，可特异性抑制肿瘤细胞基于能量的代谢。

Rh2E2, a novel metabolic suppressor, specifically inhibits energy-based metabolism of tumor cells.

作者信息

Wong Vincent Kam Wai, Dong Hang, Liang Xu, Bai Li-Ping, Jiang Zhi-Hong, Guo Yue, Kong Ah Ng Tony, Wang Rui, Kam Richard Kin Ting, Law Betty Yuen Kwan, Hsiao Wendy Wen Luen, Chan Ka Man, Wang Jingrong, Chan Rick Wai Kit, Guo Jianru, Zhang Wei, Yen Feng Gen, Zhou Hua, Leung Elaine Lai Han, Yu Zhiling, Liu Liang

机构信息

State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macau, China.

Shum Yiu Foon Shum Bik Chuen Memorial Centre for Cancer and Inflammation Research, School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China.

出版信息

Oncotarget. 2016 Mar 1;7(9):9907-24. doi: 10.18632/oncotarget.6934.

DOI:10.18632/oncotarget.6934
PMID:26799418
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4891092/
Abstract

Energy metabolism in cancer cells is often increased to meet their higher proliferative rate and biosynthesis demands. Suppressing cancer cell metabolism using agents like metformin has become an attractive strategy for treating cancer patients. We showed that a novel ginsenoside derivative, Rh2E2, is as effective as aspirin in preventing the development of AOM/DSS-induced colorectal cancer and suppresses tumor growth and metastasis in a LLC-1 xenograft. A sub-chronic and acute toxicity LD50 test of Rh2E2 showed no harmful reactions at the maximum oral dosage of 5000 mg/kg body weight in mice. Proteomic profiling revealed that Rh2E2 specifically inhibited ATP production in cancer cells via down-regulation of metabolic enzymes involving glycolysis, fatty acid β-oxidation and the tricarboxylic acid cycle, leading to specific cytotoxicity and S-phase cell cycle arrest in cancer cells. Those findings suggest that Rh2E2 possesses a novel and safe anti-metabolic agent for cancer patients by specific reduction of energy-based metabolism in cancer cells.

摘要

癌细胞中的能量代谢通常会增加，以满足其更高的增殖率和生物合成需求。使用二甲双胍等药物抑制癌细胞代谢已成为治疗癌症患者的一种有吸引力的策略。我们发现，一种新型人参皂苷衍生物Rh2E2在预防AOM/DSS诱导的结直肠癌发展方面与阿司匹林同样有效，并且在LLC-1异种移植模型中可抑制肿瘤生长和转移。Rh2E2的亚慢性和急性毒性LD50测试表明，在小鼠口服最大剂量为5000 mg/kg体重时未出现有害反应。蛋白质组学分析显示，Rh2E2通过下调参与糖酵解、脂肪酸β-氧化和三羧酸循环的代谢酶，特异性抑制癌细胞中的ATP生成，从而导致癌细胞出现特异性细胞毒性和S期细胞周期阻滞。这些发现表明，Rh2E2通过特异性降低癌细胞中基于能量的代谢，为癌症患者提供了一种新型且安全的抗代谢药物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b666/4891092/9882408fb0a9/oncotarget-07-09907-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b666/4891092/00ad63867cff/oncotarget-07-09907-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b666/4891092/151a580d1ebe/oncotarget-07-09907-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b666/4891092/b06efc6009c3/oncotarget-07-09907-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b666/4891092/f19fbbfc2d99/oncotarget-07-09907-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b666/4891092/55d550b94968/oncotarget-07-09907-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b666/4891092/bc318442cdef/oncotarget-07-09907-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b666/4891092/9882408fb0a9/oncotarget-07-09907-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b666/4891092/00ad63867cff/oncotarget-07-09907-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b666/4891092/151a580d1ebe/oncotarget-07-09907-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b666/4891092/b06efc6009c3/oncotarget-07-09907-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b666/4891092/f19fbbfc2d99/oncotarget-07-09907-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b666/4891092/55d550b94968/oncotarget-07-09907-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b666/4891092/bc318442cdef/oncotarget-07-09907-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b666/4891092/9882408fb0a9/oncotarget-07-09907-g007.jpg

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本文引用的文献

1
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J Biol Chem. 2015 Apr 10;290(15):9571-87. doi: 10.1074/jbc.M114.617837. Epub 2015 Feb 26.
2
Glutamate dehydrogenase 1 signals through antioxidant glutathione peroxidase 1 to regulate redox homeostasis and tumor growth.谷氨酸脱氢酶 1 通过抗氧化谷胱甘肽过氧化物酶 1 信号传递来调节氧化还原稳态和肿瘤生长。
Cancer Cell. 2015 Feb 9;27(2):257-70. doi: 10.1016/j.ccell.2014.12.006.
3
Regulation of mammalian nucleotide metabolism and biosynthesis.
膳食植物化学物针对肺癌干预和预防的潜在分子生物标志物研究进展
Pharm Res. 2023 Nov;40(11):2699-2714. doi: 10.1007/s11095-023-03595-w. Epub 2023 Sep 19.
4
Enolase 1, a Moonlighting Protein, as a Potential Target for Cancer Treatment.烯醇化酶 1，一种兼性 Moonlighting 蛋白，作为癌症治疗的潜在靶点。
Int J Biol Sci. 2021 Sep 21;17(14):3981-3992. doi: 10.7150/ijbs.63556. eCollection 2021.
5
CGA ameliorates cognitive decline by regulating the PI3K/AKT signaling pathway and neurotransmitter systems in rats with multi-infarct dementia.矢车菊素-3-O-葡萄糖苷通过调节多梗死性痴呆大鼠的PI3K/AKT信号通路和神经递质系统来改善认知功能衰退。
Exp Ther Med. 2020 Nov;20(5):70. doi: 10.3892/etm.2020.9198. Epub 2020 Sep 9.
6
Novel ginsenoside derivative 20(S)-Rh2E2 suppresses tumor growth and metastasis in vivo and in vitro via intervention of cancer cell energy metabolism.新型人参皂苷衍生物 20(S)-Rh2E2 通过干预癌细胞能量代谢，在体内和体外抑制肿瘤生长和转移。
Cell Death Dis. 2020 Aug 14;11(8):621. doi: 10.1038/s41419-020-02881-4.
7
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8
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9
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5
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7
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8
Anti-diabetic drug metformin: challenges and perspectives for cancer therapy.抗糖尿病药物二甲双胍：癌症治疗面临的挑战与前景
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9
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10
The role of tumor suppressor p53 in the antioxidant defense and metabolism.肿瘤抑制因子p53在抗氧化防御和代谢中的作用。
Subcell Biochem. 2014;85:337-58. doi: 10.1007/978-94-017-9211-0_18.