Shin Dong-Sik, Matharu Zimple, You Jungmok, Siltanen Christian, Vu Tam, Raghunathan Vijay Krishna, Stybayeva Gulnaz, Hill Ashley E, Revzin Alexander
Department of Biomedical Engineering, University of California, Davis, CA, 95616, USA.
Department of Medical & Pharmaceutical Sciences, Sookmyung Women's University, Seoul, 140-742, Republic of Korea.
Adv Healthc Mater. 2016 Mar;5(6):659-64, 627. doi: 10.1002/adhm.201500571. Epub 2016 Jan 22.
Conducting polymer hydrogel is fabricated atop gold or ITO electrodes and is functionalized with monoclonal antibodies. Binding of interferon-γ molecules causes redox properties of conductive hydrogel to change in a concentration-dependent fashion without the need for washing or sample handling steps. This conductive hydrogel remains functional in a fouling media such as whole blood.
导电聚合物水凝胶是在金或氧化铟锡（ITO）电极上制备的，并通过单克隆抗体进行功能化。干扰素-γ分子的结合会使导电水凝胶的氧化还原特性以浓度依赖的方式发生变化，而无需洗涤或样品处理步骤。这种导电水凝胶在全血等污染介质中仍能保持功能。
