Kasperska-Zajac A, Damasiewicz-Bodzek A, Tyrpień-Golder K, Zamlyński J, Grzanka A
Department of Internal Diseases, Dermatology and Allergology in Zabrze, SMDZ in Zabrze, Medical University of Silesia in Katowice, ul. M. Curie-Skłodowskiej 10, 41-800, Zabrze, Poland.
Department of Chemistry in Zabrze, SMDZ in Zabrze, Medical University of Silesia in Katowice, Katowice, Poland.
Inflamm Res. 2016 May;65(5):343-6. doi: 10.1007/s00011-016-0914-5. Epub 2016 Jan 22.
Activation of receptor for advanced glycation end products (RAGE) leads to the proinflammatory response and the release of its soluble form (sRAGE) which appears to function as an anti-inflammatory feedback mechanism.
To determine serum sRAGE concentration in CSU patients and its association with C-reactive protein (CRP) concentration, a nonspecific inflammatory marker of the disease activity.
Concentrations of sRAGE and CRP were measured in serum of CSU patients and compared with the healthy controls.
Serum sRAGE concentrations were significantly decreased in CSU patients, especially those more severely affected. In addition, significant inverse correlations were observed between sRAGE and CRP concentrations.
Down-regulation of sRAGE and its association with acute phase response suggest a role for RAGE activation in the pathogenesis of CSU. It seems that lower serum sRAGE concentration may enhance the urticarial processes.
晚期糖基化终末产物受体（RAGE）的激活会引发促炎反应，并释放其可溶性形式（sRAGE），而sRAGE似乎起到抗炎反馈机制的作用。
测定慢性自发性荨麻疹（CSU）患者血清sRAGE浓度及其与C反应蛋白（CRP）浓度的关系，CRP是该疾病活动的非特异性炎症标志物。
测定CSU患者血清中sRAGE和CRP的浓度，并与健康对照进行比较。
CSU患者血清sRAGE浓度显著降低，尤其是病情较重的患者。此外，sRAGE与CRP浓度之间存在显著的负相关。
sRAGE的下调及其与急性期反应的关联表明RAGE激活在CSU发病机制中起作用。似乎较低的血清sRAGE浓度可能会加剧荨麻疹病程。
