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慢性自发性荨麻疹患者中的白细胞介素-6转信号传导

IL-6 Transsignaling in Patients with Chronic Spontaneous Urticaria.

作者信息

Kasperska-Zajac Alicja, Grzanka Alicja, Damasiewicz-Bodzek Aleksandra

机构信息

Department of Internal Diseases, Dermatology and Allergology in Zabrze, SMDZ in Zabrze, Medical University of Silesia in Katowice, Poland.

Department of Chemistry in Zabrze, Medical University of Silesia in Katowice, SMDZ in Zabrze, Poland.

出版信息

PLoS One. 2015 Dec 23;10(12):e0145751. doi: 10.1371/journal.pone.0145751. eCollection 2015.

DOI:10.1371/journal.pone.0145751
PMID:26699882
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4689405/
Abstract

BACKGROUND

IL-6 trans-signaling is critically involved in the initiation and promotion of inflammatory and autoimmune diseases. Therefore, we investigated the clinical relevance of soluble members of IL-6 trans-signaling system in chronic spontaneous urticaria (CSU).

METHODS

IL-6, interleukin 6 soluble receptor (IL-6 sR) and soluble gp130 (sgp130) were measured by ELISA method in plasma from CSU patients and the healthy subjects. The data were related to activation of the acute phase response as indicated by serum C-reactive protein (CRP) concentration and compared between patients stratified by the disease activity.

RESULTS

Concentrations of IL-6, IL-6 sR, sgp130 in plasma and CRP in serum were significantly elevated in CSU patients compared with the healthy controls. CRP correlated significantly with IL-6 and sgp130, similarly IL-6 correlated significantly with sgp130. By contrast, CRP and IL-6 did not correlate significantly with IL-6 sR. However, significant correlation was noted between IL-6 sR and sgp130.

CONCLUSIONS

Concentrations of IL-6 and its soluble receptors were significantly elevated in patients with CSU, suggesting upregulation of the IL-6 trans-signaling in the disease. In addition, our results support the concept that the system may be involved in pathogenesis of the systemic inflammatory activation in CSU patients.

摘要

背景

白细胞介素-6（IL-6）转导信号在炎症和自身免疫性疾病的起始和进展过程中起关键作用。因此，我们研究了IL-6转导信号系统可溶性成员在慢性自发性荨麻疹（CSU）中的临床相关性。

方法

采用酶联免疫吸附测定（ELISA）法检测CSU患者和健康对照者血浆中的IL-6、白细胞介素6可溶性受体（IL-6 sR）和可溶性糖蛋白130（sgp130）。数据与血清C反应蛋白（CRP）浓度所指示的急性期反应激活情况相关，并在按疾病活动度分层的患者之间进行比较。

结果

与健康对照相比，CSU患者血浆中的IL-6、IL-6 sR、sgp130以及血清中的CRP浓度显著升高。CRP与IL-6和sgp130显著相关，同样，IL-6与sgp130也显著相关。相比之下，CRP和IL-6与IL-6 sR无显著相关性。然而，IL-6 sR与sgp130之间存在显著相关性。

结论

CSU患者中IL-6及其可溶性受体的浓度显著升高，提示该疾病中IL-6转导信号上调。此外，我们的结果支持这样一种观点，即该系统可能参与了CSU患者全身炎症激活的发病机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1e6/4689405/a3db88cbc3bf/pone.0145751.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1e6/4689405/2dd778d00c6d/pone.0145751.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1e6/4689405/15eedccad015/pone.0145751.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1e6/4689405/ffc1e2438695/pone.0145751.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1e6/4689405/af28df0231e2/pone.0145751.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1e6/4689405/a3db88cbc3bf/pone.0145751.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1e6/4689405/2dd778d00c6d/pone.0145751.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1e6/4689405/15eedccad015/pone.0145751.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1e6/4689405/ffc1e2438695/pone.0145751.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1e6/4689405/af28df0231e2/pone.0145751.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1e6/4689405/a3db88cbc3bf/pone.0145751.g005.jpg

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