Tsuka Takeshi, Morita Takehito, Tanaka Hinako, Kono Shinji, Murahata Yusuke, Azuma Kazuo, Osaki Tomohiro, Ito Norihiko, Okamoto Yoshiharu, Imagawa Tomohiro
Department of Veterinary Clinical Medicine, School of Veterinary Medicine, Faculty of Agriculture, Tottori University, 4-101, Koyama-Minami, Tottori, Tottori, Japan.
Tobu Veterinary Clinic, Tottori Prefectural Federation Agricultural Mutual Aid Association, 210-19, Takadote, Kuniyasu, Tottori, Tottori, Japan.
BMC Vet Res. 2016 Jan 22;12:19. doi: 10.1186/s12917-016-0637-4.
All of oral hamartomas has been previously found in mandibular gingiva in younger calves, and were histologically diagnosed as a vascular hamartoma. This is the first case report describing a calf with a mass in the maxillary gingiva that was histologically diagnosed as a nasal tissue-derived hamartoma.
A 13-day-old male Holstein calf presented with a horn-like mass in the left rostral maxillary gingiva. Surgical removal revealed that the mass had a dual structure composed of cartilaginous and soft tissues and extended deeply toward the nasal cavity. Excised tissues mainly consisted of two types of mature cells without mitotic figures and atypia: 1) the cartilage-like structures consisted of an island and a meandering massive focus of mature cartilaginous tissues, and 2) tubular structures consisting of stratified ciliated mucosal columnar cells with gland-like structures and aggregated goblet cells. The mass was diagnosed as a nasal tissue-derived hamartoma because these two types of structures were histologically identical to nasal structures. The present case had no recurrence at 1 year after surgery.
To our knowledge, this is the first description of the calf with nasal tissue-derived hamartoma in the maxillary gingiva.
此前发现所有口腔错构瘤均位于较年幼犊牛的下颌牙龈，且经组织学诊断为血管性错构瘤。本文是首例描述上颌牙龈出现肿物且经组织学诊断为鼻组织源性错构瘤的犊牛病例报告。
一头13日龄雄性荷斯坦犊牛，左侧上颌前部牙龈出现一个角状肿物。手术切除显示该肿物具有由软骨组织和软组织构成的双重结构，并深深延伸至鼻腔。切除组织主要由两种无有丝分裂象和异型性的成熟细胞组成：1）软骨样结构由成熟软骨组织的岛状和蜿蜒状大块病灶组成；2）管状结构由具有腺样结构和聚集杯状细胞的分层纤毛黏膜柱状细胞组成。由于这两种结构在组织学上与鼻结构相同，该肿物被诊断为鼻组织源性错构瘤。本病例术后1年无复发。
据我们所知，本文是对上颌牙龈出现鼻组织源性错构瘤犊牛的首例描述。
