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癌症转移的原因:整体视角。

Reasons for cancer metastasis: A holistic perspective.

作者信息

Wang Rui-An, Lu You-Yong, Fan Dai-Ming

机构信息

State Key Laboratory of Cancer Biology, The Fourth Military Medical University, Xi'an, Shaanxi 710032, P.R. China; Department of Pathology, Xijing Hospital, The Fourth Military Medical University, Xi'an, Shaanxi 710032, P.R. China; Department of Pathology and Pathophysiology, The Fourth Military Medical University, Xi'an, Shaanxi 710032, P.R. China.

Laboratory of Molecular Oncology, Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education, Peking University Cancer Hospital and Institute, Beijing 100142, P.R. China.

出版信息

Mol Clin Oncol. 2015 Nov;3(6):1199-1202. doi: 10.3892/mco.2015.623. Epub 2015 Aug 14.

Abstract

Over several years, scientists investigating cancer have focused their efforts on elucidating the mechanisms underlying cancer metastasis, with the aim of finding a way to inhibit this process. These mechanisms, however, only explain the process of cancer metastasis, but do not explain why cancer would metastasize in the first place. Cancer metastasizes due to several factors, namely attack by the immune system, lack of oxygen and necessary nutrients, large amounts of lactic acid produced by glycolysis and increased cell death. Therefore, the majority of the presently available treatments for cancer also bear the potential to induce metastasis. Thus, it is crucial in medical practice to minimize the risk of cancer metastasis during a time when there are no effective means to inhibit this process.

摘要

多年来,研究癌症的科学家们一直致力于阐明癌症转移的潜在机制,以期找到抑制这一过程的方法。然而,这些机制仅解释了癌症转移的过程,却并未说明癌症最初为何会发生转移。癌症转移是由多种因素导致的,即免疫系统的攻击、缺氧和必需营养物质的缺乏、糖酵解产生大量乳酸以及细胞死亡增加。因此,目前大多数现有的癌症治疗方法也有可能诱发转移。所以,在尚无有效手段抑制癌症转移的情况下,在医疗实践中尽量降低癌症转移的风险至关重要。

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