Rani R, Mittal K K
Indian J Pediatr. 1989 Mar-Apr;56(2):181-7. doi: 10.1007/BF02726602.
The neuroendocrine system helps in the success of the fetal graft by suppressing maternal cellular immune response against the foreign paternal histocompatibility (HLA) antigens. In addition, placenta absorbs the antibodies directed against the paternal HLA antigens, thus inhibiting the humoral rejection of the fetal graft. In contrast, neuropeptides released in the maternal blood stream under adverse mental states may stimulate lymphocyte blastogenesis and natural killer (NK) cell activity resulting in premature loss of the fetus. Further, homozygosity of a lethal gene which is in linkage disequilibrium with HLA genes may have a role in some unexplained fetal deaths.
神经内分泌系统通过抑制母体针对外来父系组织相容性（HLA）抗原的细胞免疫反应，来帮助胎儿移植物成功着床。此外，胎盘会吸收针对父系HLA抗原的抗体，从而抑制胎儿移植物的体液排斥反应。相反，在不良精神状态下母体血流中释放的神经肽可能会刺激淋巴细胞增殖和自然杀伤（NK）细胞活性，导致胎儿过早流失。此外，与HLA基因处于连锁不平衡状态的致死基因纯合性可能在一些不明原因的胎儿死亡中起作用。
