Müller K H, Pflugshaupt C
Hautarzt. 1989;40 Suppl 9:1-12.
In the main this first part of a review of the literature was already published 10 years ago. Here the importance of urea in the normal and diseased skin and its various dermopharmacologic properties is dealth with. For the time being the publications of the seventies are given special attention. In them particularly the utilization of the keratolytic and hydrating properties, i.e. water-binding capacity, of urea in the horny layer and also its significance in the treatment of hyperkeratosis and xerotic dermatosis without serious side effects is emphasized.
总体而言,这篇文献综述的第一部分早在10年前就已发表。本文论述了尿素在正常皮肤和病变皮肤中的重要性及其各种皮肤药理学特性。目前,特别关注20世纪70年代的出版物。其中特别强调了尿素在角质层中的角质溶解和保湿特性,即水结合能力,以及其在治疗角化过度和干性皮肤病方面的意义,且无严重副作用。