Nenoff P, Donaubauer K, Arndt T, Haustein U-F
Laboratorium für medizinische Mikrobiologie, Mölbis.
Hautarzt. 2004 Jan;55(1):58-64. doi: 10.1007/s00105-003-0647-6.
Currently, there are no data on how the topical application of amino acids influences the complex moisture retaining system of the skin in vivo.
PATIENTS/METHODS: An open study was performed to investigate the effects of topical application of arginine hydrochloride on epidermal stratum corneum urea content, transepidermal water loss, skin hydration, and clinical status of patients with atopic dermatitis and dry elderly skin.
Treatment of patients with atopic dermatitis with 2.5% arginine hydrochloride ointment over 4 weeks showed a significant increase in urea in the stratum corneum as well as a continuous increase in skin moisture.
The urea deficit in the stratum corneum in atopic dermatitis and elderly skin was corrected not by applying the moisturizer urea itself but instead by using arginine - its precursor in the Krebs-Henseleit urea cycle. This topical treatment also improved the clinical symptoms of dry skin.
目前，尚无关于局部应用氨基酸如何在体内影响皮肤复杂保湿系统的数据。
患者/方法：开展一项开放性研究，以调查局部应用盐酸精氨酸对特应性皮炎患者和干性老年皮肤患者的表皮角质层尿素含量、经表皮水分流失、皮肤水合作用及临床状况的影响。
用2.5%盐酸精氨酸软膏治疗特应性皮炎患者4周后，角质层中的尿素显著增加，皮肤水分也持续增加。
特应性皮炎和老年皮肤角质层中的尿素缺乏并非通过应用保湿剂尿素本身得以纠正，而是通过使用精氨酸——其为克雷布斯-亨泽莱特尿素循环中的前体得以纠正。这种局部治疗还改善了干性皮肤的临床症状。
