Drosner M
Dermatologische Klinik und Poliklinik, Technischen Universität München.
Hautarzt. 1989;40 Suppl 9:47-50.
Tar distillates and topical corticosteroids are still being used to treat chronic eczema. With the use of halogenised corticosteroids local and systemic side-effects are increasing. There fore this both doctor and patient often reject treatment. To avoid this a local treatment with corticosteroids should be effective without having side-effects. In a double-blind investigation we compared a new preparation of 1% hydrocortisone plus 10% urea with hydrocortisone 17-valerate in the treatment of atopic dermatitis. There was no difference between the two preparations concerning the improvement of symptoms and the course of the disease. However, as opposed to the monopreparation, the combination of hydrocortisone and urea caused no side-effects.
焦油馏分物和外用皮质类固醇仍用于治疗慢性湿疹。随着卤化皮质类固醇的使用，局部和全身副作用不断增加。因此，医生和患者常常拒绝这种治疗方法。为避免这种情况，外用皮质类固醇治疗应有效且无副作用。在一项双盲研究中，我们比较了1%氢化可的松加10%尿素的新制剂与17-戊酸氢化可的松治疗特应性皮炎的效果。两种制剂在症状改善和疾病进程方面没有差异。然而，与单一制剂不同，氢化可的松和尿素的组合未引起副作用。
