Key Laboratory of Magnetic Materials and Devices & Division of Functional Materials and Nano Devices, Ningbo Institute of Materials Technology & Engineering, Chinese Academy of Sciences, Ningbo 315201, China.
Regen Biomater. 2015 Sep;2(3):215-9. doi: 10.1093/rb/rbv013. Epub 2015 Aug 7.
Neuropeptide Y (NPY) was first identified from porcine brain in 1982, and plays its biological functions in humans through NPY receptors (Y1, Y2, Y4 and Y5). NPY receptors are known to mediate various physiological functions and involve in a majority of human diseases, such as obesity, hypertension, epilepsy and metabolic disorders. Recently, NPY receptors have been found to be overexpressed in many cancers, so they emerged as promising target in cancer diagnosis and therapy. This review focuses on the latest research about NPY and NPY receptors, and summarizes the current knowledge on NPY receptors expression in cancers, selective ligands for NPY receptors and their application in cancer imaging and therapy.
神经肽 Y（NPY）于 1982 年首次从猪脑中被鉴定出来，通过 NPY 受体（Y1、Y2、Y4 和 Y5）在人体内发挥其生物学功能。已知 NPY 受体介导各种生理功能，并涉及大多数人类疾病，如肥胖、高血压、癫痫和代谢紊乱。最近，人们发现 NPY 受体在许多癌症中过度表达，因此它们成为癌症诊断和治疗有前途的靶点。本综述重点介绍了 NPY 和 NPY 受体的最新研究进展，总结了 NPY 受体在癌症中的表达、NPY 受体的选择性配体及其在癌症成像和治疗中的应用的现有知识。
