Lee Jung Hyun, Kim Yu-Mi, Kwak Min Jung, Kim Su Yung, Kim Hyun-Ji, Cheon Chong Kun, Chung Woo Yeong, Choi Im-Jeong, Hong Su Young, Chueh Hee Won, Yoo Jae-Ho
Department of Pediatrics, Kosin University Gospel Hospital, Kosin University College of Medicine, Busan, Korea.
Department of Preventive Medicine, Dong-A University College of Medicine, Busan, Korea.
Ann Pediatr Endocrinol Metab. 2015 Dec;20(4):206-12. doi: 10.6065/apem.2015.20.4.206. Epub 2015 Dec 31.
This study investigated the incidence trends and associated factors of type 1 (T1DM) and type 2 diabetes mellitus (T2DM) in children and adolescents under 15 years of age in Busan and Gyeongnam, Korea from 2001 to 2010.
Medical records of newly diagnosed diabetes patients (n=328; 160 males, 168 females) were collected in questionnaire form from 5 tertiary and 42 general hospitals in Busan and Gyeongnam.
The average crude incidence rate of T1DM and T2DM was 2.01/100,000 (95% confidence interval [CI], 1.76-2.28) and 0.75/100,000 (95% CI, 0.60-0.92), respectively. The incidence rate ratio (IRR) of T1DM was 1.31 (95% CI, 1.01-1.69), and that of T2DM was 1.97 (95% CI, 1.25-3.11) in the latter half-decade (2006 to 2010) compared to the early half-decade (2001 to 2005). There were gradually increasing incidence trends in both T1DM and T2DM over the 10-year period (P for trend: T1DM, 0.0009; T2DM, <0.0001). Age-specific IRR was highest in the 10- to 14-year-old group, regardless of diabetes type. In particular, a rapid increase in incidence of T2DM occurred in the 10- to 14-year-old group. IRR for females was 1.07 (95% CI, 0.83-1.38) for T1DM and 1.56 (95% CI, 1.01-2.41) for T2DM. IRR for Busan (urban) was 1.41 (95% CI, 1.09-1.83) for T1DM and 1.49 (95% CI, 0.96-2.30) for T2DM.
T1DM and T2DM incidence both increased over time in youth under age 15 living in Busan and Gyeongnam; in particular, the incidence of T2DM in adolescents increased more rapidly.
本研究调查了2001年至2010年韩国釜山和庆南15岁以下儿童及青少年1型糖尿病（T1DM）和2型糖尿病（T2DM）的发病率趋势及相关因素。
以问卷形式从釜山和庆南的5家三级医院和42家综合医院收集新诊断糖尿病患者（n = 328；男160例，女168例）的病历。
T1DM和T2DM的平均粗发病率分别为2.01/100,000（95%置信区间[CI]，1.76 - 2.28）和0.75/100,000（95% CI，0.60 - 0.92）。与前五年（2001年至2005年）相比，后五年（2006年至2010年）T1DM的发病率比（IRR）为1.31（95% CI，1.01 - 1.69），T2DM的发病率比为1.97（95% CI，1.25 - 3.11）。在这10年期间，T1DM和T2DM的发病率均呈逐渐上升趋势（趋势P值：T1DM为0.0009；T2DM＜0.0001）。无论糖尿病类型如何，10至14岁年龄组的年龄别发病率比最高。特别是，10至14岁年龄组的T2DM发病率迅速上升。女性T1DM的发病率比为1.07（95% CI，0.83 - 1.38），T2DM的发病率比为1.56（95% CI，1.01 - 2.41）。釜山（城市）T1DM的发病率比为1.41（95% CI，1.09 - 1.83），T2DM的发病率比为1.49（95% CI，0.96 - 2.30）。
釜山和庆南15岁以下青少年中，T1DM和T2DM的发病率均随时间增加；特别是青少年中T2DM的发病率上升更快。
