Kim Jae Hyun, Lee Chong Guk, Lee Young Ah, Yang Sei Won, Shin Choong Ho
Department of Pediatrics, Inje University College of Medicine, Ilsan Paik Hospital, Goyang, Korea.
Department of Pediatrics, Asan Chungmu Hospital, Asan-si, Korea.
Pediatr Diabetes. 2016 Nov;17(7):519-524. doi: 10.1111/pedi.12324. Epub 2015 Sep 30.
The incidence of type 1 diabetes mellitus (T1DM) in children and adolescents has increased worldwide. However, the epidemiology of T1DM among Korean youth has not been reported since 2001. We investigated the incidence of T1DM in Korean children and adolescents from 2012 to 2014 and compared it with data from 1995 to 2000.
Data were obtained from the National Health Insurance Service (NHIS) registry, and age- and sex-specific incidence rates were calculated per 100 000 population.
In total, 706 patients (326 boys and 380 girls, aged <15 yr) with T1DM were registered in the NHIS during 2012-2014. The incidence rate per 100 000 population was 3.19 (95% confidence interval [CI] 2.96-3.43). We found incidence rates of 1.68, 3.16, and 4.46 in children 0-4, 5-9, and 10-14 yr, respectively. The T1DM incidence was 2.84 in boys and 3.56 in girls. A higher T1DM incidence was seen during 2012-2014 than from 1995-2000 (incidence rate ratio 2.33; p < 0.001). The incidence rate ratios between 1995-2000 and 2012-2014 were 2.31, 2.20, and 2.27 in children 0-4, 5-9, and 10-14 yr, respectively. The annual increase in T1DM incidence was 5.6% (95% CI 5.0-6.3%) between 1995 and 2014.
We observed a significant increase in the T1DM incidence. This increase was higher in boys than in girls, and was highest in children aged 0-4 yr. Studies are needed to evaluate the long-term epidemiological trend of T1DM incidence.
全球儿童和青少年1型糖尿病（T1DM）的发病率呈上升趋势。然而，自2001年以来，韩国青少年T1DM的流行病学情况尚未见报道。我们调查了2012年至2014年韩国儿童和青少年T1DM的发病率，并与1995年至2000年的数据进行了比较。
数据来自国民健康保险服务（NHIS）登记处，计算每10万人口中按年龄和性别的发病率。
2012年至2014年期间，NHIS共登记了706例T1DM患者（326名男孩和380名女孩，年龄<15岁）。每10万人口的发病率为3.19（95%置信区间[CI]2.96-3.43）。我们发现0-4岁、5-9岁和10-14岁儿童的发病率分别为1.68、3.16和4.46。男孩的T1DM发病率为2.84，女孩为3.56。2012年至2014年期间的T1DM发病率高于1995年至2000年（发病率比2.33；p<0.001）。1995年至2000年与2012年至2014年之间，0-4岁、5-9岁和10-14岁儿童的发病率比分别为2.31、2.20和2.27。1995年至2014年期间，T1DM发病率的年增长率为5.6%（95%CI 5.0-6.3%）。
我们观察到T1DM发病率显著上升。男孩的发病率上升幅度高于女孩，0-4岁儿童的发病率最高。需要开展研究以评估T1DM发病率的长期流行病学趋势。
