Department of Pediatrics, Hallym University Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea.
Department of Pediatrics, Ajou University School of Medicine, Ajou University Hospital, San 5, Wonchon-dong, Yeongtong-gu, Suwon, 443-721, Korea.
Sci Rep. 2021 Dec 8;11(1):23660. doi: 10.1038/s41598-021-03138-6.
The purpose of this study was to present age- and sex-specific distributions of the triglyceride-glucose (TyG) index and to evaluate their relationship with cardiometabolic risk factors in children and adolescents. A total of 7404 participants aged 10-18 years from the Korean National Health and Nutrition Survey were included as the reference population. The TyG index was calculated as ln(fasting triglyceride [mg/dL] × fasting glucose [mg/dL]/2). The percentile of the TyG index exhibited a steady linear relationship with age for both sexes. TyG index significantly correlated with waist circumference (WC) standard deviation score (SDS; r = 0.110, p < 0.001), systolic blood pressure (SBP; r = 0.104, p < 0.001), diastolic blood pressure (DBP; r = 0.083, p < 0.001), glucose (r = 0.220, p < 0.001), high-density lipoprotein cholesterol (HDL-C; r = - 0.325, p < 0.001), and triglycerides (TG; r = 0.926, p < 0.001). Multiple linear regression analysis revealed that the TyG index was significantly associated with WC SDS (β = 0.116, p < 0.001), SBP (β = 2.009, p < 0.001), DBP (β = 1.464, p < 0.001), glucose (β = 3.376, p < 0.001), HDL-C (β = - 6.431, p < 0.001), and TG (β = 85.518, p < 0.001). Our results suggest that the TyG index has a steady linear distribution for sex and age in children and adolescents and constitutes an indicator for predicting metabolic disorders that could lead to cardiovascular disease later in life.
本研究旨在呈现甘油三酯-葡萄糖（TyG）指数在儿童和青少年中的年龄和性别特异性分布，并评估其与心血管代谢危险因素的关系。本研究共纳入了来自韩国国家健康和营养调查的 7404 名 10-18 岁的参与者作为参考人群。TyG 指数的计算方法为 ln（空腹甘油三酯[mg/dL]×空腹血糖[mg/dL]/2）。对于男性和女性，TyG 指数的百分位数与年龄呈稳定的线性关系。TyG 指数与腰围（WC）标准差评分（SDS；r=0.110，p<0.001）、收缩压（SBP；r=0.104，p<0.001）、舒张压（DBP；r=0.083，p<0.001）、血糖（r=0.220，p<0.001）、高密度脂蛋白胆固醇（HDL-C；r=-0.325，p<0.001）和甘油三酯（TG；r=0.926，p<0.001）显著相关。多元线性回归分析显示，TyG 指数与 WC SDS（β=0.116，p<0.001）、SBP（β=2.009，p<0.001）、DBP（β=1.464，p<0.001）、血糖（β=3.376，p<0.001）、HDL-C（β=-6.431，p<0.001）和 TG（β=85.518，p<0.001）显著相关。我们的研究结果表明，在儿童和青少年中，TyG 指数的性别和年龄呈稳定的线性分布，是预测代谢紊乱的指标，这些代谢紊乱可能导致以后发生心血管疾病。
