Rosario Gracy Xavier, Stewart Colin L
Developmental and Regenerative Biology, Institute of Medical Biology, Singapore City, Singapore.
Am J Reprod Immunol. 2016 Mar;75(3):246-55. doi: 10.1111/aji.12474. Epub 2016 Jan 28.
Embryo implantation is mediated by the combined actions of the ovarian hormones E2 and P4 on the uterus. In addition, the pro-inflammatory cytokine, leukaemia inhibitory factor (LIF), plays a pivotal role in regulating uterine receptivity. LIF is expressed in the endometrial glands and has a robust action on the uterine luminal epithelium (LE). In mice, LIF is induced by nidatory E2 and functions to convert the LE from a non-receptive to an embryo-responsive state. LIF mediates its actions by activating the JAK-STAT pathway specifically in the LE. Activation of JAK-STAT pathway results in the induction of many additional pathways, including some 40 + transcription factors, many of which initiate a cascade of changes affecting epithelial polarity, epithelial-mesenchymal interactions, angiogenesis, stromal cell decidualization, and inhibiting cell proliferation. This review discusses the role of LIF and the recent analysis of its action on the uterine LE in regulating endometrial receptivity and implantation.
胚胎着床是由卵巢激素E2和P4对子宫的联合作用介导的。此外，促炎细胞因子白血病抑制因子（LIF）在调节子宫容受性方面起着关键作用。LIF在内膜腺中表达，对子宫腔上皮（LE）有强大作用。在小鼠中，着床期E2诱导LIF表达，其作用是将LE从非容受状态转变为对胚胎有反应的状态。LIF通过特异性激活LE中的JAK-STAT信号通路来介导其作用。JAK-STAT信号通路的激活会诱导许多其他信号通路，包括约40多种转录因子，其中许多会引发一系列影响上皮极性、上皮-间质相互作用、血管生成、基质细胞蜕膜化以及抑制细胞增殖的变化。本文综述了LIF的作用以及近期对其在调节子宫内膜容受性和着床过程中对子宫LE作用的分析。
