Dantas Thinali Sousa, de Barros Silva Paulo Goberlânio, Sousa Eric Fernandes, da Cunha Maria do Pss, de Aguiar Andréa Silvia Walter, Costa Fábio Wildson Gurgel, Mota Mário Rogério Lima, Alves Ana Paula Negreiros Nunes, Sousa Fabrício Bitu
From the Laboratory of Oral Pathology, Federal University of Ceará (TSD, PGDBS); Ceará School of Oncology, Haroldo Juaçaba Hospital (EFS, MDPDC, FBS); Division of Diplomacy Health (ASWDA); Division of Oral Radiology and Imaginology (FWGS); Laboratory of Oral Pathology (MRLM, APNNA); and Laboratory of Oral Pathology, Federal University of Ceará, Fortaleza, Ceará, Brazil (FBS).
Medicine (Baltimore). 2016 Jan;95(3):e2314. doi: 10.1097/MD.0000000000002314.
The mortality rate associated with oral cancer is estimated at approximately 12,300 deaths per year, and the survival rate is only 40% to 50% for diagnosed patients and is closely related to the duration of time between disease perception and its diagnosis and treatment. Socioeconomic risk factors are determinants of the incidence and mortality related to oral cancer. We conducted a retrospective, cross-sectional study of 573 records of patients with oral cancer at Haroldo Juaçaba Hospital - Cancer Institute of Ceará from 2000 to 2009 to evaluate the influence of socioeconomic factors on survival and epidemiological behavior of this neoplasia in a Brazilian population. In this study, patients with oral cancer were males greater than 60 years of age, presented squamous cell carcinoma in the floor of mouth and were characterized by low education levels. A total of 573 lesions were found in oral cavities. Cox proportional hazards regression model showed that the histological type, tumor stage, and low degree of education significantly influenced survival. A lower patient survival rate was correlated with a more advanced stage of disease and a worse prognosis. Squamous cell carcinoma is associated with a higher mortality when compared with other histological types of malign neoplasia.
口腔癌的死亡率估计约为每年12300人死亡，确诊患者的生存率仅为40%至50%，且与疾病察觉与其诊断和治疗之间的时间长短密切相关。社会经济风险因素是与口腔癌相关的发病率和死亡率的决定因素。我们对2000年至2009年期间在哈罗尔多·朱阿萨巴医院——塞阿拉癌症研究所的573例口腔癌患者记录进行了一项回顾性横断面研究，以评估社会经济因素对巴西人群中这种肿瘤的生存和流行病学行为的影响。在这项研究中，口腔癌患者为60岁以上男性，表现为口底鳞状细胞癌，且以低教育水平为特征。在口腔中共发现573个病灶。Cox比例风险回归模型显示，组织学类型、肿瘤分期和低教育程度显著影响生存。患者生存率较低与疾病分期更晚和预后更差相关。与其他组织学类型的恶性肿瘤相比，鳞状细胞癌的死亡率更高。
