German Center for Health Services Research in Dermatology (CVderm), Institute for Health Services Research in Dermatology and Nursing (IVDP), University Medical Center Hamburg-Eppendorf (UKE), Martinistraße 52, 20246, Hamburg, Germany.
Am J Clin Dermatol. 2016 Apr;17(2):163-9. doi: 10.1007/s40257-015-0171-3.
Health-related quality of life (HRQoL) is often markedly impaired in both adults and children with atopic dermatitis. The quality of life of the parents of infants or children with this chronic disease is also affected owing to problems such as itch-induced sleeping problems and treatment effort. As HRQoL is only partly associated with disease severity, both parameters should be evaluated in research and clinical practice. For the measurement of HRQoL, both skin- and disease-specific questionnaires are available in addition to generic instruments. In randomized controlled trials on atopic dermatitis, HRQoL is most commonly evaluated with the Dermatology Life Quality Index for use in adults and related questionnaires for children and families, such as the Children's Dermatology Life Quality Index. There is evidence that different treatment modalities may be effective in improving HRQoL in adults, children, and parents, which is supported by the patients' own evaluation of treatment benefit in an observational study.
特应性皮炎患者的生活质量（HRQoL）无论在成人还是儿童中都受到显著影响。由于瘙痒导致的睡眠问题和治疗负担等问题，患有这种慢性疾病的婴儿或儿童的父母的生活质量也受到影响。由于 HRQoL 仅部分与疾病严重程度相关，因此在研究和临床实践中都应评估这两个参数。除了通用工具外，还可以使用皮肤和疾病特异性问卷来测量 HRQoL。在特应性皮炎的随机对照试验中，最常用于评估成人 HRQoL 的是皮肤病生活质量指数，以及针对儿童和家庭的相关问卷，如儿童皮肤病生活质量指数。有证据表明，不同的治疗方式可能对改善成人、儿童和父母的 HRQoL 有效，这一观点得到了观察性研究中患者对治疗获益的自我评价的支持。
