Department of Molecular Biosciences, The University of Texas at Austin, Austin, Texas 78712, USA.
Nat Cell Biol. 2016 Feb;18(2):141-2. doi: 10.1038/ncb3306.
The control of proteasome-mediated protein degradation is thought to occur mainly at the level of polyubiquitylation of the substrate. However, the proteasome can also be regulated directly, as now demonstrated by a study in which DYRK2-mediated phosphorylation of the 19S subunit Rpt3 is found to increase proteasome activity.
蛋白质降解的蛋白酶体介导的控制被认为主要发生在底物多泛素化的水平上。然而，蛋白酶体也可以被直接调节，正如现在的一项研究所示，该研究发现 DYRK2 介导的 19S 亚基 Rpt3 的磷酸化可增加蛋白酶体的活性。
