Wang Karin, Cai Li-Heng, Lan Bo, Fredberg Jeffrey J
Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Harvard School of Engineering and Applied Sciences, Cambridge, Massachusetts, USA.
Nat Methods. 2016 Feb;13(2):124-5. doi: 10.1038/nmeth.3744.
To drive its migration through a fibrillar matrix—and thus to spread, invade or metastasize—a cancer cell must exert physical forces. The first visualization of these forces in three dimensions reveals surprising migration dynamics.
为了驱动其在纤维状基质中迁移，从而实现扩散、侵袭或转移，癌细胞必须施加物理力。对这些力在三维空间中的首次可视化揭示了惊人的迁移动态。
